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    Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [ Mus musculus (house mouse) ]

    Gene ID: 50933, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Uchl3provided by MGI
    Official Full Name
    ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)provided by MGI
    Primary source
    MGI:MGI:1355274
    See related
    Ensembl:ENSMUSG00000022111 AllianceGenome:MGI:1355274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UCH-L3
    Summary
    Enables deubiquitinase activity. Involved in cellular response to insulin stimulus; positive regulation of fat cell differentiation; and protein catabolic process. Acts upstream of or within several processes, including adult walking behavior; eating behavior; and protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo ectoderm; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 31.8), testis adult (RPKM 30.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uchl3 in Genome Data Viewer
    Location:
    14 E2.3; 14 50.9 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (101891387..101933561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (101653892..101696125)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 4 Neighboring gene predicted gene, 34417 Neighboring gene STARR-seq mESC enhancer starr_37476 Neighboring gene STARR-positive B cell enhancer ABC_E7344 Neighboring gene STARR-positive B cell enhancer ABC_E8574 Neighboring gene COMM domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_37480 Neighboring gene STARR-positive B cell enhancer ABC_E2432 Neighboring gene STARR-seq mESC enhancer starr_37481 Neighboring gene STARR-positive B cell enhancer ABC_E11786 Neighboring gene HCLS1 associated X-1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37482 Neighboring gene predicted gene 9922

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses. Setsuie R, et al. Neurochem Int, 2010 Jul. PMID 20380862
    2. Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle. Setsuie R, et al. FASEB J, 2009 Dec. PMID 19671667
    3. Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. Sano Y, et al. Am J Pathol, 2006 Jul. PMID 16816367, Free PMC Article
    4. Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Wood MA, et al. Hippocampus, 2005. PMID 15884048
    5. Expression and functional analysis of Uch-L3 during mouse development. Kurihara LJ, et al. Mol Cell Biol, 2000 Apr. PMID 10713173, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
      Title: Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
    2. The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
      Title: The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
    3. Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.
      Title: Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.
    4. subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex
      Title: Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
    5. impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie
      Title: Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
    6. Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 signaling
      Title: Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation.
    7. Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.
      Title: Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
    8. Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner.
      Title: Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis.
    9. The role of ubiquitin C-terminal hydrolase (UCH)-L3 in the regulation of AMP-activated protein kinase activity and whole-body energy metabolism are reportedl
      Title: Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
    10. Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.
      Title: The hippocampal proteomic analysis of senescence-accelerated mouse: implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within eating behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L3
    Names
    ubiquitin thioesterase L3
    ubiquitin thiolesterase
    NP_057932.2
    XP_006519309.1
    XP_006519310.3
    XP_006519311.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428941.1 → NP_001415870.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025630
      UniProtKB/TrEMBL
      A0A2I3BQ39

    2. NM_001428942.1 → NP_001415871.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025630

    3. NM_001428943.1 → NP_001415872.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025630

    4. NM_001428944.1 → NP_001415873.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025630

    5. NM_016723.3 → NP_057932.2  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 3

      See identical proteins and their annotated locations for NP_057932.2

      Status: VALIDATED

      Source sequence(s)
      CT025630
      Consensus CDS
      CCDS27313.1
      UniProtKB/Swiss-Prot
      Q9EQX7, Q9JKB1
      Related
      ENSMUSP00000002289.6, ENSMUST00000002289.8
      Conserved Domains (1) summary
      cd09616
      Location:6 → 227
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      101891387..101933561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519246.5 → XP_006519309.1  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1

      Conserved Domains (1) summary
      cd09616
      Location:39 → 365
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    2. XM_006519248.4 → XP_006519311.3  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3

      Conserved Domains (1) summary
      cd09616
      Location:39 → 301
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    3. XM_006519247.4 → XP_006519310.3  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BQ39
      Related
      ENSMUSP00000154032.2, ENSMUST00000226340.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKB1.2 GenPept UniProtKB/Swiss-Prot:Q9JKB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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