Pirb paired Ig-like receptor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pirbprovided by MGI
Official Full Name: paired Ig-like receptor Bprovided by MGI
Primary source: MGI:MGI:894311
See related: Ensembl:ENSMUSG00000058818 AllianceGenome:MGI:894311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gp91; LIR-3; PIR-B; Lilrb3
Summary: Enables amyloid-beta binding activity and protein homodimerization activity. Involved in learning or memory; regulation of protein metabolic process; and regulation of synaptic plasticity. Acts upstream of or within several processes, including B cell homeostasis; B cell mediated immunity; and myeloid dendritic cell differentiation. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular space. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and ganglionic eminence. Orthologous to several human genes including LILRB5 (leukocyte immunoglobulin like receptor B5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 40.8), mammary gland adult (RPKM 24.0) and 14 other tissues See more
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Genomic context

Location:: 7 A1; 7 2.14 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3715504..3723381, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3712505..3720382, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.
Title: CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.
LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.
Title: LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.
PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation.
Title: PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation.
Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.
Title: Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.
LOTUS suppresses amyloid beta-induced dendritic spine elimination through the blockade of amyloid beta binding to PirB.
Title: LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.
PIR-B Regulates CD4(+) IL17a(+) T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.
Title: PIR-B Regulates CD4(+) IL17a(+) T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.
Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Title: Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.
Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.
Title: Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.
PirB functions as an intrinsic suppressor in hippocampal neural stem cells.
Title: PirB functions as an intrinsic suppressor in hippocampal neural stem cells.
structural findings and the observed PirB-MAG interactions are compatible with a model for intercellular signaling in which the PirB extracellular domains, which point away from the cell surface, enable interaction with ligands in trans
Title: Structure and flexibility of the extracellular region of the PirB receptor.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224864

42.MMHAP27FRF12.seq (e-PCR)
- UniSTS:159595

BB138245 (e-PCR)
- UniSTS:208059

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables HLA-A specific inhibitory MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables HLA-B specific inhibitory MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein complex binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables inhibitory MHC class I receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of long-term synaptic depression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor subfamily B member 3

Names: cell-surface glycoprotein p91; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; paired immunoglobulin-like receptor B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357394.1 → NP_001344323.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK142375, AK161081, BB842214

UniProtKB/TrEMBL

Q8R2Z1

Conserved Domains (1) summary

cl11960
Location:225 → 315

Ig; Immunoglobulin domain
NM_011095.2 → NP_035225.2 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_035225.2

Status: VALIDATED

Source sequence(s)

AF148880, AK161081, AK165255

Consensus CDS

CCDS39730.1

UniProtKB/Swiss-Prot

P97484

UniProtKB/TrEMBL

Q8R2Z1

Related

ENSMUSP00000077546.7, ENSMUST00000078451.7

Conserved Domains (2) summary

smart00410
Location:529 → 617

IG_like; Immunoglobulin like

cl11960
Location:225 → 315

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

3715504..3723381 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539634.4 → XP_006539697.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1

UniProtKB/TrEMBL

Q8R2Z1

Conserved Domains (1) summary

cl11960
Location:225 → 315

Ig; Immunoglobulin domain
XM_006539635.4 → XP_006539698.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2

Conserved Domains (1) summary

cl11960
Location:126 → 220

Ig; Immunoglobulin domain