Lyz1 lysozyme 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyz1provided by MGI
Official Full Name: lysozyme 1provided by MGI
Primary source: MGI:MGI:96902
See related: Ensembl:ENSMUSG00000069515 AllianceGenome:MGI:96902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyz; Lyzf3; Lzp-s
Summary: Predicted to enable identical protein binding activity and lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Is expressed in embryo mesenchyme; liver and biliary system; and small intestine. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 3054.3), small intestine adult (RPKM 742.7) and 2 other tissues See more
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Genomic context

Location:: 10 D2; 10 65.35 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (117123700..117128773, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (117287795..117292868, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal lysozyme1 deficiency alters microbiota composition and impacts host metabolism through the emergence of NAD[+]-secreting ASTB Qing110 bacteria.
Title: Intestinal lysozyme1 deficiency alters microbiota composition and impacts host metabolism through the emergence of NAD(+)-secreting ASTB Qing110 bacteria.
Results show that lysozyme (LYSO) - induced Staphylococcus aureus bacteriostasis increased with increasing concentrations of baicalin, and that baicalin binding to LYSO synergistically increased the antibacterial activity of LYSO.
Title: Baicalin promotes the bacteriostatic activity of lysozyme on S. aureus in mammary glands and neutrophilic granulocytes in mice.
These observations demonstrate that phagocytosis and lysozyme-based cell wall degradation of S. aureus are functionally coupled to NLRP3 inflammasome activation and IL-1beta secretion.
Title: Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.
These observations demonstrate that phagocytosis and lysozyme-based cell wall degradation of S. aureus are functionally coupled to NLRP3 inflammasome activation and IL-1beta secretion.
Title: Inflammasome activation: how macrophages watch what they eat.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lyz1 (e-PCR), detects polymorphism
- UniSTS:526863

AI326280 (e-PCR)
- UniSTS:180122

RH127838 (e-PCR)
- UniSTS:211148

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysozyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysozyme C-1

Names: 1,4-beta-N-acetylmuramidase C; P lysozyme structural; lysozyme C type P; lysozyme f3; renal amyloidosis

NP_038618.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.