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    Tmed5 transmembrane p24 trafficking protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 73130, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tmed5provided by MGI
    Official Full Name
    transmembrane p24 trafficking protein 5provided by MGI
    Primary source
    MGI:MGI:1921586
    See related
    Ensembl:ENSMUSG00000063406 AllianceGenome:MGI:1921586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p24gamma2; 3110020O18Rik; 4432412D15Rik
    Summary
    Predicted to be involved in Golgi ribbon formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in cis-Golgi network and endoplasmic reticulum exit site. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED5 (transmembrane p24 trafficking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 9.7), placenta adult (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 52.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108269422..108280486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108121556..108132620, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13900 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_13901 Neighboring gene STARR-seq mESC enhancer starr_13902 Neighboring gene metal response element binding transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_13904 Neighboring gene STARR-positive B cell enhancer ABC_E2166 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 8190

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystallographic analysis of murine p24γ2 Golgi dynamics domain. Nagae M, et al. Proteins, 2017 Apr. PMID 28066915
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystallographic analysis of murine p24gamma2 Golgi dynamics domain has been reported.
      Title: Crystallographic analysis of murine p24γ2 Golgi dynamics domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane emp24 domain-containing protein 5
    Names
    p24 family protein gamma-2
    transmembrane emp24 protein transport domain containing 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347383.2 → NP_001334312.1  transmembrane emp24 domain-containing protein 5 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC159996
      Consensus CDS
      CCDS84924.1
      UniProtKB/TrEMBL
      D3Z615, Q3V440
      Related
      ENSMUSP00000112612.2, ENSMUST00000117759.2

    2. NM_001361466.1 → NP_001348395.1  transmembrane emp24 domain-containing protein 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159996
      UniProtKB/TrEMBL
      Q3U9T7
      Conserved Domains (1) summary
      pfam01105
      Location:35 → 183
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    3. NM_001361467.1 → NP_001348396.1  transmembrane emp24 domain-containing protein 5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159996
      UniProtKB/TrEMBL
      D3Z615
      Conserved Domains (1) summary
      pfam01105
      Location:35 → 96
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    4. NM_028876.3 → NP_083152.1  transmembrane emp24 domain-containing protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_083152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159996, AK014490, BB376243, BB764499
      Consensus CDS
      CCDS19508.1
      UniProtKB/Swiss-Prot
      Q3TDS6, Q9CXE7
      UniProtKB/TrEMBL
      A2RS96, Q3U9T7, Q8VCE7
      Related
      ENSMUSP00000002837.5, ENSMUST00000002837.11
      Conserved Domains (1) summary
      pfam01105
      Location:35 → 222
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108269422..108280486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXE7.1 GenPept UniProtKB/Swiss-Prot:Q9CXE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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