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    Wbp2 WW domain binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 22378, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wbp2provided by MGI
    Official Full Name
    WW domain binding protein 2provided by MGI
    Primary source
    MGI:MGI:104709
    See related
    Ensembl:ENSMUSG00000034341 AllianceGenome:MGI:104709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA binding activity; estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of macromolecule metabolic process; and response to steroid hormone. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. Is expressed in epidermis and epidermis stratum basale. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to human WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 171.5), duodenum adult (RPKM 125.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 80.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115969397..115977821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116078571..116086995, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31192 Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene STARR-positive B cell enhancer ABC_E8471 Neighboring gene STARR-seq mESC enhancer starr_31193 Neighboring gene tripartite motif-containing 47 Neighboring gene tripartite motif-containing 65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. Zheng Z, et al. Cell Death Dis, 2021 Mar 3. PMID 33658485, Free PMC Article
    2. Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. Buniello A, et al. EMBO Mol Med, 2016 Mar 1. PMID 26881968, Free PMC Article
    3. Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability. Field NS, et al. Eur J Immunol, 2020 Oct. PMID 32459862, Free PMC Article
    4. Characterization of a novel protein-binding module--the WW domain. Sudol M, et al. FEBS Lett, 1995 Aug 1. PMID 7641887
    5. Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway. Lim SK, et al. FASEB J, 2011 Sep. PMID 21642474

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKbeta1.
      Title: WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1.
    2. This study established WBP2 as a tyrosine phosphorylation target of estrogen signaling via EGFR crosstalk.
      Title: Tyrosine phosphorylation of transcriptional coactivator WW-domain binding protein 2 regulates estrogen receptor α function in breast cancer via the Wnt pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to progesterone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-binding protein 2
    Names
    WBP-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347642.1 → NP_001334571.1  WW domain-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI837765, AI844895, AK043037, AL607108, DV657565
      Consensus CDS
      CCDS83934.1
      UniProtKB/Swiss-Prot
      P97765
      UniProtKB/TrEMBL
      Q544A1
      Related
      ENSMUSP00000102052.4, ENSMUST00000106444.4

    2. NM_001361446.1 → NP_001348375.1  WW domain-binding protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and contains an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant. 1. The encoded isoform (3) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL607108
      Conserved Domains (1) summary
      cd13214
      Location:30 → 131
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    3. NM_016852.3 → NP_058548.1  WW domain-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_058548.1

      Status: VALIDATED

      Source sequence(s)
      AL607108
      Consensus CDS
      CCDS25657.1
      UniProtKB/Swiss-Prot
      A2A860, P97765
      UniProtKB/TrEMBL
      Q3TRG5, Q544A1
      Related
      ENSMUSP00000074204.7, ENSMUST00000074628.13
      Conserved Domains (1) summary
      cd13214
      Location:30 → 131
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115969397..115977821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97765.1 GenPept UniProtKB/Swiss-Prot:P97765

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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