Cops6 COP9 signalosome subunit 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cops6provided by MGI
Official Full Name: COP9 signalosome subunit 6provided by MGI
Primary source: MGI:MGI:1349439
See related: Ensembl:ENSMUSG00000019494 AllianceGenome:MGI:1349439
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgn3; VIP/MOV34
Summary: Predicted to enable isopeptidase activity and metallopeptidase activity. Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including central nervous system; liver; male reproductive system; sensory organ; and urinary system. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 77.2), testis adult (RPKM 73.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.97 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (138159364..138162246)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (138161102..138163984)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
Title: CSN6 aggravates Ang II-induced cardiomyocyte hypertrophy via inhibiting SIRT2.
CSN6 and Rab34 are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis.
Title: CSN6 and Rab34 Are Involved in Androgen Receptor Trafficking in Mouse Testicular Sertoli Cells.
results define a mechanism for the regulation of Myc stability through the CSN-Cullin-Fbxw7 axis and provide insights into the correlation of CSN6 overexpression with Myc stabilization/activation during tumorigenesis
Title: CSN6 drives carcinogenesis by positively regulating Myc stability.
loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway
Title: Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein deneddylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 6

Names: COP9 (constitutive photomorphogenic) homolog, subunit 6; COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6; JAB1-containing signalosome subunit 6; SGN6; signalosome subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012002.3 → NP_036132.1 COP9 signalosome complex subunit 6

See identical proteins and their annotated locations for NP_036132.1

Status: PROVISIONAL

Source sequence(s)

AC151719

Consensus CDS

CCDS19792.1

UniProtKB/Swiss-Prot

O88545

UniProtKB/TrEMBL

Q3UIT2

Related

ENSMUSP00000019638.9, ENSMUST00000019638.15

Conserved Domains (1) summary

cd08063
Location:36 → 318

MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6