CCL26 C-C motif chemokine ligand 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCL26provided by HGNC
Official Full Name: C-C motif chemokine ligand 26provided by HGNC
Primary source: HGNC:HGNC:10625
See related: Ensembl:ENSG00000006606 MIM:604697; AllianceGenome:HGNC:10625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
Summary: This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]
Expression: Broad expression in ovary (RPKM 2.0), adrenal (RPKM 0.7) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q11.23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (75769524..75791597, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (77056596..77078673, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (75398842..75420915, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The functional role of CST1 and CCL26 in asthma development.
Title: The functional role of CST1 and CCL26 in asthma development.
Th2 cytokine signaling through IL-4Ralpha increases eotaxin-3 secretion and tension in human esophageal smooth muscle.
Title: Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle.
MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease.
Title: MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive Pulmonary Disease.
[Expression and predictive value of type inflammatory cytokines in nasal secretion in eosinophilic chronic rhinosinusitis with nasal polyps].
Title: [Expression and predictive value of type Ⅱ inflammatory cytokines in nasal secretion in eosinophilic chronic rhinosinusitis with nasal polyps].
Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
Title: Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway.
Title: CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway.
Type-2 Cytokines Promote the Secretion of the Eosinophil-Attractant CCL26 by Intestinal Epithelial Cells in Food-Sensitized Patients.
Title: Type-2 Cytokines Promote the Secretion of the Eosinophil-Attractant CCL26 by Intestinal Epithelial Cells in Food-Sensitized Patients.
Analysis of the signal cross talk via CCL26 in the tumor microenvironment in osteosarcoma.
Title: Analysis of the signal cross talk via CCL26 in the tumor microenvironment in osteosarcoma.
Hypoxia directed migration of human naive monocytes is associated with an attenuation of cytokine release: indications for a key role of CCL26.
Title: Hypoxia directed migration of human naïve monocytes is associated with an attenuation of cytokine release: indications for a key role of CCL26.
Increased serum CCL26 level is a potential biomarker for the effectiveness of anti-PD1 antibodies in patients with advanced melanoma.
Title: Increased serum CCL26 level is a potential biomarker for the effectiveness of anti-PD1 antibodies in patients with advanced melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of CCL26 in human monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481549

D7S1500 (e-PCR)
- UniSTS:46099

D7S1500 (e-PCR)
- UniSTS:63258

NoName (e-PCR)
- UniSTS:483045

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR3 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables CX3C chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-C motif chemokine 26

Names: CC chemokine IMAC; MIP-4-alpha; chemokine (C-C motif) ligand 26; chemokine N1; eotaxin-3; macrophage inflammatory protein 4-alpha; small inducible cytokine A26; small inducible cytokine subfamily A (Cys-Cys), member 26; thymic stroma chemokine-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015989.1 RefSeqGene

Range

22536..25209

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001371936.1 → NP_001358865.1 C-C motif chemokine 26 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AC005102

Consensus CDS

CCDS5578.1

UniProtKB/Swiss-Prot

A0N0Q5, Q52LV8, Q9Y258

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
NM_001371938.1 → NP_001358867.1 C-C motif chemokine 26 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a shorter 5' UTR compared to variant 1 since it represents use of the main transcription initiation site, as defined by CAGE data. All three variants encode the same protein.

Source sequence(s)

AC005102

Consensus CDS

CCDS5578.1

UniProtKB/Swiss-Prot

A0N0Q5, Q52LV8, Q9Y258

Related

ENSP00000005180.4, ENST00000005180.9

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...
NM_006072.4 → NP_006063.1 C-C motif chemokine 26 precursor

See identical proteins and their annotated locations for NP_006063.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AF096296, AY358893

Consensus CDS

CCDS5578.1

UniProtKB/Swiss-Prot

A0N0Q5, Q52LV8, Q9Y258

Related

ENSP00000378365.2, ENST00000394905.2

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an ...