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    CPVL carboxypeptidase vitellogenic like [ Homo sapiens (human) ]

    Gene ID: 54504, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CPVLprovided by HGNC
    Official Full Name
    carboxypeptidase vitellogenic likeprovided by HGNC
    Primary source
    HGNC:HGNC:14399
    See related
    Ensembl:ENSG00000106066 MIM:609780; AllianceGenome:HGNC:14399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HVLP
    Summary
    The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in spleen (RPKM 87.7), thyroid (RPKM 67.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CPVL in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28994636..29195451, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29132164..29333261, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29034252..29235067, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29061318-29062086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29062087-29062854 Neighboring gene CPVL antisense RNA 2 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene uncharacterized LOC128966558 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:29165822-29167021 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:29178298-29179497 Neighboring gene CPVL antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29235044-29235679 Neighboring gene CHN2 antisense RNA 1 Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. Mahoney JA, et al. Genomics, 2001 Mar 15. PMID 11401439
    2. Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis. Striebich CC, et al. J Immunol, 1998 Oct 15. PMID 9780222
    3. CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients. Hu C, et al. Diabetes, 2011 Nov. PMID 21911749, Free PMC Article
    4. Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. Ignatovich O, et al. J Mol Biol, 1999 Nov 26. PMID 10610771
    5. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Maeda S, et al. Diabetes, 2010 Aug. PMID 20460425, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPVL suppresses metastasis of nasopharyngeal carcinoma through inhibiting epithelial-mesenchymal transition.
      Title: CPVL suppresses metastasis of nasopharyngeal carcinoma through inhibiting epithelial-mesenchymal transition.
    2. genetic association studies in a Chinese population with type 2 diabetes: An SNP in CPVL (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
      Title: CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog
    Genome-wide association study of atypical psychosis.
    EBI GWAS Catalog
    Genome-wide association with diabetes-related traits in the Framingham Heart Study.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of vitellogenic-like carboxypeptidase (CPVL) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC10029

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    probable serine carboxypeptidase CPVL
    Names
    CP-Mac carboxypeptidase
    VCP-like protein
    carboxypeptidase WUG
    vitellogenic carboxypeptidase-like protein
    NP_001334981.1
    NP_001334983.1
    NP_001358184.1
    NP_001358185.1
    NP_001358186.1
    NP_001358187.1
    NP_001358189.1
    NP_001358190.1
    NP_001358191.1
    NP_001358192.1
    NP_001358193.1
    NP_001358194.1
    NP_001358195.1
    NP_001358196.1
    NP_001358197.1
    NP_061902.2
    NP_112601.3
    XP_011513739.1
    XP_016867855.1
    XP_047276486.1
    XP_047276487.1
    XP_054214475.1
    XP_054214476.1
    XP_054214477.1
    XP_054214478.1
    XP_054214479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348052.1 → NP_001334981.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    2. NM_001348054.1 → NP_001334983.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    3. NM_001371255.1 → NP_001358184.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    4. NM_001371256.1 → NP_001358185.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    5. NM_001371257.1 → NP_001358186.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    6. NM_001371258.1 → NP_001358187.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    7. NM_001371260.1 → NP_001358189.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Related
      ENSP00000387164.1, ENST00000409850.5
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    8. NM_001371261.1 → NP_001358190.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    9. NM_001371262.1 → NP_001358191.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    10. NM_001371263.1 → NP_001358192.1  probable serine carboxypeptidase CPVL isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    11. NM_001371264.1 → NP_001358193.1  probable serine carboxypeptidase CPVL isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) encodes the longest isoform (a).
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      UniProtKB/TrEMBL
      B3KW79

    12. NM_001371265.1 → NP_001358194.1  probable serine carboxypeptidase CPVL isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform c.
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      UniProtKB/TrEMBL
      B3KW79

    13. NM_001371266.1 → NP_001358195.1  probable serine carboxypeptidase CPVL isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      UniProtKB/TrEMBL
      B3KW79

    14. NM_001371267.1 → NP_001358196.1  probable serine carboxypeptidase CPVL isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform c.
      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096
      UniProtKB/TrEMBL
      B3KW79

    15. NM_001371268.1 → NP_001358197.1  probable serine carboxypeptidase CPVL isoform d

      Status: REVIEWED

      Source sequence(s)
      AC004593, AC005162, AC005232, AC007096

    16. NM_019029.3 → NP_061902.2  probable serine carboxypeptidase CPVL isoform b precursor

      See identical proteins and their annotated locations for NP_061902.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC005162, AK075433, BC016838
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Related
      ENSP00000379572.3, ENST00000396276.7
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    17. NM_031311.5 → NP_112601.3  probable serine carboxypeptidase CPVL isoform b precursor

      See identical proteins and their annotated locations for NP_112601.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
      Source sequence(s)
      AC005162, AK075433
      Consensus CDS
      CCDS5419.1
      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Related
      ENSP00000265394.5, ENST00000265394.10
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      28994636..29195451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012366.2 → XP_016867855.1  probable serine carboxypeptidase CPVL isoform X2

      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      cl08270
      Location:69 → 377
      Peptidase_S10; Serine carboxypeptidase

    2. XM_047420531.1 → XP_047276487.1  probable serine carboxypeptidase CPVL isoform X2

    3. XM_011515437.2 → XP_011513739.1  probable serine carboxypeptidase CPVL isoform X1

      See identical proteins and their annotated locations for XP_011513739.1

      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
      UniProtKB/TrEMBL
      B3KW79
      Conserved Domains (1) summary
      pfam00450
      Location:69 → 466
      Peptidase_S10; Serine carboxypeptidase

    4. XM_047420530.1 → XP_047276486.1  probable serine carboxypeptidase CPVL isoform X1

      UniProtKB/Swiss-Prot
      A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      29132164..29333261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358500.1 → XP_054214475.1  probable serine carboxypeptidase CPVL isoform X1

    2. XM_054358501.1 → XP_054214476.1  probable serine carboxypeptidase CPVL isoform X1

    3. XM_054358503.1 → XP_054214478.1  probable serine carboxypeptidase CPVL isoform X2

    4. XM_054358504.1 → XP_054214479.1  probable serine carboxypeptidase CPVL isoform X2

    5. XM_054358502.1 → XP_054214477.1  probable serine carboxypeptidase CPVL isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H3G5.2 GenPept UniProtKB/Swiss-Prot:Q9H3G5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
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