Aurkb aurora kinase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aurkbprovided by RGD
Official Full Name: aurora kinase Bprovided by RGD
Primary source: RGD:621625
See related: Ensembl:ENSRNOG00000005659 AllianceGenome:RGD:621625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aim1; ARK-2; STK-1; Stk12
Summary: Enables protein kinase activity. Involved in aging; cell population proliferation; and cleavage furrow formation. Located in midbody and spindle. Orthologous to human AURKB (aurora kinase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 175.8), Lung (RPKM 119.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54243116..54249675)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (53744290..53750831)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55625860..55632399)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc7 kinase stimulates Aurora B kinase in M-phase.
Title: Cdc7 kinase stimulates Aurora B kinase in M-phase.
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
Title: A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport.
findings indicated that aurora kinase B plays a critical role in spinal microgliosis and neuropathic pain
Title: Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury.
RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase.
Title: In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.
when overexpressed in megakaryocytes of transgenic mice, the phenotype includes increased transgenic mRNA, but not protein, in polyploidy megakaryocytes, further suggesting that Aurora-B is regulated at the protein level.
Title: Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression.
Results suggest that the activities of Aurora kinases A and B are required for normal spindle assembly as well as for establishment and maintenance of proper microtubule-kinetochore attachments and spindle checkpoint signaling in male mammalian meiosis.
Title: Inhibition of Aurora kinases perturbs chromosome alignment and spindle checkpoint signaling in rat spermatocytes.
Aurora B kinase during mitosis and cytokinesis
Title: Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129726 (e-PCR)
- UniSTS:213021

Aurkb (e-PCR), detects polymorphism
- UniSTS:265048

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in abscission	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cleavage furrow formation	IEA Inferred from Electronic Annotation more info
involved_in cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cleavage furrow formation	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cGAS/STING signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic sister chromatid segregation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of telomere capping	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromocenter	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase B

Names: AIM-1; aurora 1; aurora- and Ipl1-like midbody-associated protein 1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B

NP_446201.1

EC 2.7.11.1

XP_006246631.1

EC 2.7.11.1

XP_006246632.1

EC 2.7.11.1

XP_008765980.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053749.2 → NP_446201.1 aurora kinase B

See identical proteins and their annotated locations for NP_446201.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O55099, Q4V8N1

UniProtKB/TrEMBL

A6HFM8

Related

ENSRNOP00000008492.3, ENSRNOT00000008492.7

Conserved Domains (1) summary

cd14117
Location:75 → 342

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54243116..54249675

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767758.2 → XP_008765980.1 aurora kinase B isoform X1

See identical proteins and their annotated locations for XP_008765980.1

UniProtKB/Swiss-Prot

O55099, Q4V8N1

UniProtKB/TrEMBL

A6HFM8

Conserved Domains (1) summary

cd14117
Location:75 → 342

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
XM_006246569.5 → XP_006246631.1 aurora kinase B isoform X1

See identical proteins and their annotated locations for XP_006246631.1

UniProtKB/Swiss-Prot

O55099, Q4V8N1

UniProtKB/TrEMBL

A6HFM8

Conserved Domains (1) summary

cd14117
Location:75 → 342

STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins
XM_006246570.5 → XP_006246632.1 aurora kinase B isoform X2

Conserved Domains (2) summary

smart00220
Location:39 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:34 → 301

PKc_like; Protein Kinases, catalytic domain