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    CNPY2 canopy FGF signaling regulator 2 [ Homo sapiens (human) ]

    Gene ID: 10330, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CNPY2provided by HGNC
    Official Full Name
    canopy FGF signaling regulator 2provided by HGNC
    Primary source
    HGNC:HGNC:13529
    See related
    Ensembl:ENSG00000257727 MIM:605861; AllianceGenome:HGNC:13529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSAP; TMEM4; ZSIG9; HP10390
    Summary
    Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 22.5), adrenal (RPKM 21.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56309844..56316346, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56277503..56283991, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56703628..56710130, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:56660797-56661296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6486 Neighboring gene Sharpr-MPRA regulatory region 15563 Neighboring gene coenzyme Q10A Neighboring gene citrate synthase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56693295-56693812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4557 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6488 Neighboring gene MPRA-validated peak1741 silencer Neighboring gene CNPY2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56709757-56710345 Neighboring gene MPRA-validated peak1742 silencer Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56730556-56731403 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56731981-56733180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29688 Neighboring gene interleukin 23 subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Canopy Homolog 2 Expression Predicts Poor Prognosis in Hepatocellular Carcinoma with Tumor Hemorrhage. Wang D, et al. Cell Physiol Biochem, 2018. PMID 30415246
    2. CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer. Yu D, et al. Biomed Pharmacother, 2018 Jul. PMID 29864955
    3. The CNPY2 enhances epithelial-mesenchymal transition via activating the AKT/GSK3β pathway in non-small cell lung cancer. Dou Y, et al. Cell Biol Int, 2018 Aug. PMID 29569784
    4. Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis. Peng J, et al. Aging (Albany NY), 2017 Nov 13. PMID 29135454, Free PMC Article
    5. MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. Bornhauser BC, et al. Cell Mol Life Sci, 2005 Jun. PMID 15905959

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression.
      Title: Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression.
    2. Hypoxia-induced CNPY2 upregulation promotes glycolysis in cervical cancer through activation of AKT pathway.
      Title: Hypoxia-induced CNPY2 upregulation promotes glycolysis in cervical cancer through activation of AKT pathway.
    3. miR30a3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2.
      Title: miR‑30a‑3p suppresses the proliferation and migration of lung adenocarcinoma cells by downregulating CNPY2.
    4. Knockout of Cnpy2 resulted in up-regulation of p16(INK4a).
      Title: Knockout of Canopy 2 activates p16(INK4a) pathway to impair cardiac repair.
    5. This study showed that serum CNPY2 isoform 2 may be a valuable biomarker for the early detection of colorectal cancer and presents an improvement in the diagnostic efficiency by combination of CEA and CA19-9.
      Title: Serum CNPY2 isoform 2 represents a novel biomarker for early detection of colorectal cancer.
    6. CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage.
      Title: Canopy Homolog 2 Expression Predicts Poor Prognosis in Hepatocellular Carcinoma with Tumor Hemorrhage.
    7. Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT.
      Title: The CNPY2 enhances epithelial-mesenchymal transition via activating the AKT/GSK3β pathway in non-small cell lung cancer.
    8. CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer.
      Title: CNPY2 enhances resistance to apoptosis induced by cisplatin via activation of NF-κB pathway in human non-small cell lung cancer.
    9. CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients.
      Title: Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis.
    10. These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression.
      Title: CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CS

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of positive regulation of low-density lipoprotein receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of regulation of low-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein canopy homolog 2
    Names
    MIR-interacting saposin-like protein
    putative secreted protein Zsig9
    transmembrane protein 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190991.3 → NP_001177920.1  protein canopy homolog 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001177920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA515271, BC001027, BF526446, DA833421
      UniProtKB/TrEMBL
      F8W1U5
      Conserved Domains (1) summary
      pfam11938
      Location:27 → 64
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    2. NM_014255.7 → NP_055070.1  protein canopy homolog 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW293214, AY359102, BE699270, BE858097
      Consensus CDS
      CCDS8914.1
      UniProtKB/Swiss-Prot
      B2R7B9, Q9UHE9, Q9Y2B0
      UniProtKB/TrEMBL
      F8VXJ7
      Related
      ENSP00000273308.4, ENST00000273308.9
      Conserved Domains (1) summary
      pfam11938
      Location:27 → 165
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56309844..56316346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56277503..56283991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2B0.1 GenPept UniProtKB/Swiss-Prot:Q9Y2B0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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