Stau2 staufen double-stranded RNA binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stau2provided by RGD
Official Full Name: staufen double-stranded RNA binding protein 2provided by RGD
Primary source: RGD:621479
See related: Ensembl:ENSRNOG00000042458 AllianceGenome:RGD:621479
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including Hsp70 protein binding activity; kinesin binding activity; and mitogen-activated protein kinase binding activity. Involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Part of messenger ribonucleoprotein complex. Used to study microphthalmia. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 204.5), Heart (RPKM 102.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (7623528..7868206)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (2840741..3084935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (2257910..2497429)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons.
Title: RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons.
RBP Stau2 plays an important role in the regulation of specific aspects of hippocampal synaptic plasticity and learning and memory.
Title: Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats.
results identify the retained intron as a critical element in recruiting Stau2, which then allows for the localization of Calm3L mRNA to distal dendrites
Title: A retained intron in the 3'-UTR of Calm3 mRNA mediates its Staufen2- and activity-dependent localization to neuronal dendrites.
Here, we describe a new role for the ATP-dependent helicase UPF1 and its interaction with the RNA localization protein STAU2 in mediating mGluR-LTD through the regulation of mRNA translation complexes stalled at the level of elongation and/or termination.
Title: UPF1 Governs Synaptic Plasticity through Association with a STAU2 RNA Granule.
Stau2 stabilizes expression of Rgs4 mRNA via its 3' UTR in hippocampal neurons.
Title: Staufen2 regulates neuronal target RNAs.
Stau2 isoforms expressed in the developing eye of chicken embryo prevent microphthalmia.
Title: The double-stranded RNA-binding protein Staufen 2 regulates eye size.
Recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs.
Title: Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression
Title: Staufen 2 regulates mGluR long-term depression and Map1b mRNA distribution in hippocampal neurons.
These results represent an additional and important step in the characterization of Staufen2- mediated neuronal functions in rat brains.
Title: Genome wide identification of Staufen2-bound mRNAs in embryonic rat brains.
provide new tools to study and understand how Stau2-containing mRNPs are transported, translationally silenced during transport and/or locally expressed according to cell needs
Title: Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138848 (e-PCR)
- UniSTS:220935

RH137896 (e-PCR)
- UniSTS:219983

Stau2 (e-PCR), detects polymorphism
- UniSTS:547731

RH135083 (e-PCR)
- UniSTS:218360

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterograde dendritic transport of messenger ribonucleoprotein complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular mRNA localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: double-stranded RNA-binding protein Staufen homolog 2

Names: r-staufen protein; staufen, RNA binding protein, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007149.2 → NP_001007150.2 double-stranded RNA-binding protein Staufen homolog 2 isoform LL (A)

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q68SB1, Q68SB2, Q68SB3, Q68SB4, Q8R4C9, Q8R4D0

UniProtKB/TrEMBL

A6JFB1

Related

ENSRNOP00000092247.1, ENSRNOT00000120142.1

Conserved Domains (5) summary

pfam16482
Location:457 → 524

Staufen_C; Staufen C-terminal domain

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:3 → 70

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_001007150.2 → NP_001007151.1 double-stranded RNA-binding protein Staufen homolog 2 isoform SS

See identical proteins and their annotated locations for NP_001007151.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JFB3

Related

ENSRNOP00000074008.2, ENSRNOT00000090346.2

Conserved Domains (2) summary

smart00358
Location:276 → 342

DSRM; Double-stranded RNA binding motif

pfam16482
Location:425 → 480

Staufen_C; Staufen C-terminal domain
NM_001393676.1 → NP_001380605.1 double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

Related

ENSRNOP00000060092.4, ENSRNOT00000066590.4

Conserved Domains (5) summary

pfam16482
Location:457 → 512

Staufen_C; Staufen C-terminal domain

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:3 → 70

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
NM_134466.4 → NP_604461.2 double-stranded RNA-binding protein Staufen homolog 2 isoform LS (B)

See identical proteins and their annotated locations for NP_604461.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q68SB1

Conserved Domains (5) summary

pfam16482
Location:457 → 512

Staufen_C; Staufen C-terminal domain

cd19882
Location:98 → 179

DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19884
Location:206 → 272

DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cd19886
Location:304 → 389

DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

cl00054
Location:3 → 70

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

7623528..7868206

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287126.1 → XP_063143196.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3
XM_063287125.1 → XP_063143195.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X3
XM_063287123.1 → XP_063143193.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X1
XM_063287127.1 → XP_063143197.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X4
XM_063287128.1 → XP_063143198.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X5
XM_063287124.1 → XP_063143194.1 double-stranded RNA-binding protein Staufen homolog 2 isoform X2

UniProtKB/Swiss-Prot

Q68SB1, Q68SB2, Q68SB3, Q68SB4, Q8R4C9, Q8R4D0