Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adh5provided by RGD
Official Full Name: alcohol dehydrogenase 5 (class III), chi polypeptideprovided by RGD
Primary source: RGD:2292706
See related: Ensembl:ENSRNOG00000046357 AllianceGenome:RGD:2292706
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alcohol dehydrogenase (NAD+) activity. Involved in aging and ethanol catabolic process. Located in cytoplasm and nucleus. Used to study alcohol use disorder. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 446.4), Kidney (RPKM 263.2) and 9 other tissues See more
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Genomic context

Location:: 2q44

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229648557..229660964)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226975184..226987591)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243728500..243740907)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione.
Title: Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.
We have defined a novel role of GSNOR in neurite development and provide molecular insights into the control of neurite growth.
Title: Activation of GSNOR transcription by NF-κB negatively regulates NGF-induced PC12 differentiation.
ADH5, while readily expressed at the mRNA level, does not behave similarly to other mammalian ADHs investigated.
Title: Analysis of mammalian alcohol dehydrogenase 5 (ADH5): characterisation of rat ADH5 with comparisons to the corresponding human variant.

Submit: New GeneRIF Correction

General gene information

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Markers

BE108111 (e-PCR)
- UniSTS:247647

Adh5 (e-PCR), detects polymorphism
- UniSTS:461946

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	ISO Inferred from Sequence Orthology more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables formaldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ethanol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ethanol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid omega-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid omega-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within formaldehyde catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nitrosative stress	ISO Inferred from Sequence Orthology more info
involved_in response to redox state	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alcohol dehydrogenase class-3

Names: ADH-B2; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; alcohol dehydrogenase 2; alcohol dehydrogenase B2; alcohol dehydrogenase class-III; class III alcohol dehydrogenase, chi subunit; glutathione-dependent formaldehyde dehydrogenase

NP_001119592.1

EC 1.1.1.1

EC 1.1.1.284

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126120.1 → NP_001119592.1 alcohol dehydrogenase class-3

See identical proteins and their annotated locations for NP_001119592.1

Status: PROVISIONAL

Source sequence(s)

BC083724

UniProtKB/Swiss-Prot

P12711, Q5XIF8

UniProtKB/TrEMBL

A6HW34

Related

ENSRNOP00000017252.3, ENSRNOT00000017252.7

Conserved Domains (2) summary

cd08300
Location:6 → 373

alcohol_DH_class_III; class III alcohol dehydrogenases

COG1062
Location:6 → 374

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]