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    Smap1 small ArfGAP 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684800, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Smap1provided by RGD
    Official Full Name
    small ArfGAP 1provided by RGD
    Primary source
    RGD:1585595
    See related
    Ensembl:ENSRNOG00000049127 AllianceGenome:RGD:1585595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and clathrin binding activity. Predicted to be involved in regulation of clathrin-dependent endocytosis. Predicted to act upstream of or within positive regulation of erythrocyte differentiation. Predicted to be located in cytoplasm. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 138.1), Brain (RPKM 87.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smap1 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (33746489..33838488, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (26250178..26342151, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (30068888..30161753, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094843 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene 60S ribosomal protein L29-like Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. Sato Y, et al. J Biochem, 1998 Jul. PMID 9644265
    2. A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. Tanabe K, et al. Mol Biol Cell, 2005 Apr. PMID 15659652, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stromal membrane-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427332.1 → NP_001414261.1  stromal membrane-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZQ30, M0RC57

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      33746489..33838488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003750668.6 → XP_003750716.3  stromal membrane-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_003750716.3

      UniProtKB/TrEMBL
      A0A8I5ZQ30, A0A8I6AHW7
      Related
      ENSRNOP00000092575.1
      Conserved Domains (1) summary
      pfam01412
      Location:20 → 120
      ArfGap; Putative GTPase activating protein for Arf

    2. XM_039084512.2 → XP_038940440.1  stromal membrane-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQ30, A0A8I6A771
      Related
      ENSRNOP00000087115.1
      Conserved Domains (2) summary
      pfam09606
      Location:258 → 373
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd08839
      Location:21 → 120
      ArfGap_SMAP; Stromal membrane-associated proteins; a subfamily of the ArfGAP family

    3. XM_039084511.2 → XP_038940439.1  stromal membrane-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQ30
      Conserved Domains (2) summary
      pfam09606
      Location:285 → 400
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd08839
      Location:21 → 120
      ArfGap_SMAP; Stromal membrane-associated proteins; a subfamily of the ArfGAP family

    4. XM_039084513.2 → XP_038940441.1  stromal membrane-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A6JJB0, A6JJB1
      Conserved Domains (1) summary
      cl28907
      Location:1 → 35
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    Nucleotide Protein Strain
    Heading Accession and Version

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