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    Washc3 WASH complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299707, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Washc3provided by RGD
    Official Full Name
    WASH complex subunit 3provided by RGD
    Primary source
    RGD:1563761
    See related
    Ensembl:ENSRNOG00000005102 AllianceGenome:RGD:1563761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc53; RGD1563761
    Summary
    Predicted to be involved in actin filament polymerization and exocytosis. Predicted to be part of WASH complex. Orthologous to human WASHC3 (WASH complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 325.7), Testes (RPKM 235.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Washc3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24508544..24553012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22621078..22665550)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28762417..28809286)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 37 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120093767 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 32 Neighboring gene uncharacterized LOC134479855

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
    2. Retromer and sorting nexins in endosomal sorting. Gallon M, et al. Biochem Soc Trans, 2015 Feb. PMID 25619244
    3. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Derivery E, et al. Dev Cell, 2009 Nov. PMID 19922875
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WASH complex subunit 3
    Names
    WASH complex subunit CCDC53
    coiled-coil domain containing 53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106776.1 → NP_001100246.1  WASH complex subunit 3

      See identical proteins and their annotated locations for NP_001100246.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A0A8I6ATX8, A6IFN5, D3ZKX1
      Related
      ENSRNOP00000006903.5, ENSRNOT00000006903.6
      Conserved Domains (1) summary
      pfam10152
      Location:30 → 167
      CCDC53; Subunit CCDC53 of WASH complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24508544..24553012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241199.5 → XP_006241261.1  WASH complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ATX8
      Conserved Domains (1) summary
      pfam10152
      Location:30 → 166
      CCDC53; Subunit CCDC53 of WASH complex

    2. XM_063263195.1 → XP_063119265.1  WASH complex subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIR0

    3. XM_039078687.2 → XP_038934615.1  WASH complex subunit 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIR0
      Conserved Domains (1) summary
      pfam10152
      Location:30 → 144
      CCDC53; Subunit CCDC53 of WASH complex
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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