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    Mreg melanoregulin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501162, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mregprovided by RGD
    Official Full Name
    melanoregulinprovided by RGD
    Primary source
    RGD:1562333
    See related
    Ensembl:ENSRNOG00000015774 AllianceGenome:RGD:1562333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562333
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including melanocyte differentiation; melanosome transport; and minus-end-directed organelle transport along microtubule. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. Orthologous to human MREG (melanoregulin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 388.1), Muscle (RPKM 112.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (81236019..81291601, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (73786727..73842081, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (79490058..79559768, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554970 Neighboring gene uncharacterized LOC134480590 Neighboring gene small ribosomal subunit protein eS10-like Neighboring gene uncharacterized LOC134480589 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function. Rout AK, et al. Structure, 2018 Oct 2. PMID 30174147, Free PMC Article
    2. Melanoregulin is stably targeted to the melanosome membrane by palmitoylation. Wu XS, et al. Biochem Biophys Res Commun, 2012 Sep 21. PMID 22940130, Free PMC Article
    3. Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. Damek-Poprawa M, et al. J Biol Chem, 2009 Apr 17. PMID 19240024, Free PMC Article
    4. Dilute suppressor dsu acts semidominantly to suppress the coat color phenotype of a deletion mutation, dl20J, of the murine dilute locus. Moore KJ, et al. Proc Natl Acad Sci U S A, 1988 Nov. PMID 3141922, Free PMC Article
    5. dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. O'Sullivan TN, et al. Proc Natl Acad Sci U S A, 2004 Nov 30. PMID 15550542, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in melanosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within melanosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in minus-end-directed organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanoregulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192002.2 → NP_001178931.1  melanoregulin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2KAX9, D4A9U9
      Related
      ENSRNOP00000021152.3, ENSRNOT00000021152.5
      Conserved Domains (1) summary
      pfam15812
      Location:46 → 191
      MREG; Melanoregulin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      81236019..81291601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267625.1 → XP_063123695.1  melanoregulin isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP56

    2. XM_039084110.2 → XP_038940038.1  melanoregulin isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAX9, A6KFH3
      Related
      ENSRNOP00000075568.2
      Conserved Domains (1) summary
      pfam15812
      Location:2 → 137
      MREG; Melanoregulin

    3. XM_039084109.2 → XP_038940037.1  melanoregulin isoform X2

      Conserved Domains (1) summary
      pfam15812
      Location:24 → 142
      MREG; Melanoregulin

    4. XM_063267626.1 → XP_063123696.1  melanoregulin isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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