Impact impact, RWD domain protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Impactprovided by MGI
Official Full Name: impact, RWD domain proteinprovided by MGI
Primary source: MGI:MGI:1098233
See related: Ensembl:ENSMUSG00000024423 AllianceGenome:MGI:1098233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E430016J11Rik
Summary: Enables actin binding activity and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to starvation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Part of polysome. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 6.87 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (13087747..13126007)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (12954690..12992950)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability.
Title: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
segmental duplication followed by enhancement of the promoter activity is responsible for the species-specific imprinting of Impact
Title: An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors.
IMPACT ensures constant high levels of translation and low levels of CREB-2 and GADD53 in specific neuronal cells under amino acid starvation conditions.
Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048742 (e-PCR)
- UniSTS:145192

px-38b5 (e-PCR)
- UniSTS:257691

Impact (e-PCR), detects polymorphism
- UniSTS:532142

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in GCN2-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in GCN2-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoplasmic translational initiation in response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein IMPACT

Names: imprinted and ancient gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357396.1 → NP_001344325.1 protein IMPACT isoform 2

Status: VALIDATED

Source sequence(s)

AC131672, BM899561

Conserved Domains (2) summary

smart00591
Location:1 → 97

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam01205
Location:164 → 270

UPF0029; Uncharacterized protein family UPF0029
NM_008378.3 → NP_032404.1 protein IMPACT isoform 1

See identical proteins and their annotated locations for NP_032404.1

Status: VALIDATED

Source sequence(s)

AC131672, AK138136, BM899561, CJ056911

Consensus CDS

CCDS29068.1

UniProtKB/Swiss-Prot

O55091, Q3UUR6, Q9EQH0

Related

ENSMUSP00000025290.6, ENSMUST00000025290.7

Conserved Domains (2) summary

smart00591
Location:15 → 115

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam01205
Location:181 → 288

UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

13087747..13126007

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246850.3 → XP_011245152.1 protein IMPACT isoform X1

See identical proteins and their annotated locations for XP_011245152.1

Conserved Domains (2) summary

smart00591
Location:1 → 97

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam01205
Location:164 → 270

UPF0029; Uncharacterized protein family UPF0029