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    Map1lc3b microtubule-associated protein 1 light chain 3 beta [ Mus musculus (house mouse) ]

    Gene ID: 67443, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Map1lc3bprovided by MGI
    Official Full Name
    microtubule-associated protein 1 light chain 3 betaprovided by MGI
    Primary source
    MGI:MGI:1914693
    See related
    Ensembl:ENSMUSG00000031812 AllianceGenome:MGI:1914693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atg8; LC3b; Map1lc3; MAP1A/MAP1B; 1010001C15Rik
    Summary
    Predicted to enable several functions, including ceramide binding activity; microtubule binding activity; and ubiquitin protein ligase binding activity. Involved in autophagy. Acts upstream of or within positive regulation of mucus secretion. Located in autolysosome; axoneme; and membrane. Is expressed in several structures, including central nervous system; heart; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to several human genes including MAP1LC3B (microtubule associated protein 1 light chain 3 beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 80.9), adrenal adult (RPKM 77.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 70.67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122317177..122325499)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121590438..121598760)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2882 Neighboring gene nuclear encoded tRNA methionine 17 (anticodon CAT) Neighboring gene predicted gene, 17786 Neighboring gene zinc finger, CCHC domain containing 14 Neighboring gene VISTA enhancer mm323 Neighboring gene predicted gene, 46065 Neighboring gene junctophilin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice. Dhingra A, et al. Int J Mol Sci, 2023 Apr 4. PMID 37047689, Free PMC Article
    2. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. Zhu M, et al. ACS Nano, 2020 Mar 24. PMID 32057231, Free PMC Article
    3. Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B). Daniele LL, et al. Am J Physiol Cell Physiol, 2019 Dec 1. PMID 31577510, Free PMC Article
    4. Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis. Kesireddy VS, et al. FASEB J, 2019 Nov. PMID 31431059, Free PMC Article
    5. Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Dhingra A, et al. Front Cell Neurosci, 2018. PMID 30349463, Free PMC Article

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
      Title: IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B.
    2. LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
      Title: LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy.
    3. Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.
      Title: Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice.
    4. BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
      Title: BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
    5. ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
      Title: ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.
    6. Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
      Title: Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.
    7. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
      Title: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
    8. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.
      Title: STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain.
    9. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.
      Title: Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.
    10. study reveals that LC3B mediated autophagy plays essential roles in AECII by modulating the functions of proteins like cathepsin A and protects alveolar epithelial cells from apoptosis and subsequent lung injury and fibrosis.
      Title: Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118046

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3B
    Names
    MAP1 light chain 3-like protein 2
    MAP1A/MAP1B light chain 3 B
    autophagy-related protein LC3 B
    autophagy-related ubiquitin-like modifier LC3 B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364358.1 → NP_001351287.1  microtubule-associated proteins 1A/1B light chain 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC182458
      Consensus CDS
      CCDS90470.1
      UniProtKB/TrEMBL
      M0QWC2
      Related
      ENSMUSP00000137754.2, ENSMUST00000181948.2
      Conserved Domains (1) summary
      cd01611
      Location:7 → 155
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    2. NM_026160.5 → NP_080436.1  microtubule-associated proteins 1A/1B light chain 3B isoform 1

      See identical proteins and their annotated locations for NP_080436.1

      Status: VALIDATED

      Source sequence(s)
      AC182458
      Consensus CDS
      CCDS22726.1
      UniProtKB/Swiss-Prot
      Q3U9W5, Q9CQV6, Q9D1R0
      UniProtKB/TrEMBL
      Q2TBF9
      Related
      ENSMUSP00000034270.10, ENSMUST00000034270.17
      Conserved Domains (1) summary
      cd17235
      Location:5 → 119
      Ubl_ATG8_MAP1LC3B; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3B (MAP1LC3B)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122317177..122325499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQV6.3 GenPept UniProtKB/Swiss-Prot:Q9CQV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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