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    Carhsp1 calcium regulated heat stable protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 52502, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Carhsp1provided by MGI
    Official Full Name
    calcium regulated heat stable protein 1provided by MGI
    Primary source
    MGI:MGI:1196368
    See related
    Ensembl:ENSMUSG00000008393 AllianceGenome:MGI:1196368
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crhsp-24; D16Ertd465e; 1200011K09Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in regulation of mRNA stability. Located in P granule and cytosol. Part of cytoplasmic exosome (RNase complex). Is expressed in dorsal root ganglion; limb; neural tube; reproductive system; and urinary system. Orthologous to human CARHSP1 (calcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 133.4), ovary adult (RPKM 91.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 4.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8476444..8490017, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8658580..8672153, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 2 pseudogene Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E8616 Neighboring gene LITAF domain containing Neighboring gene ubiquitin specific peptidase 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8745912-8746157 Neighboring gene STARR-seq mESC enhancer starr_40018 Neighboring gene STARR-seq mESC enhancer starr_40019 Neighboring gene predicted gene, 25805

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. Pfeiffer JR, et al. Mol Cell Biol, 2011 Jan. PMID 21078874, Free PMC Article
    2. The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Wishart MJ, et al. Proc Natl Acad Sci U S A, 2002 Feb 19. PMID 11842224, Free PMC Article
    3. A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus. Baguet A, et al. J Exp Med, 2004 Dec 20. PMID 15596523, Free PMC Article
    4. Gene expression in cortical interneuron precursors is prescient of their mature function. Batista-Brito R, et al. Cereb Cortex, 2008 Oct. PMID 18250082, Free PMC Article
    5. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101919

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-regulated heat stable protein 1
    Names
    calcineurin substrate CRHSP-24
    calcium-regulated heat-stable protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025821.2 → NP_080097.1  calcium-regulated heat stable protein 1

      See identical proteins and their annotated locations for NP_080097.1

      Status: PROVISIONAL

      Source sequence(s)
      AK004711
      Consensus CDS
      CCDS27942.1
      UniProtKB/Swiss-Prot
      Q9CR86
      UniProtKB/TrEMBL
      Q3U434, Q3UD53, Q5M9P7
      Related
      ENSMUSP00000008537.9, ENSMUST00000008537.10
      Conserved Domains (1) summary
      cd04458
      Location:64 → 129
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      8476444..8490017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522347.3 → XP_006522410.1  calcium-regulated heat stable protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3U434, Q3UD53
      Conserved Domains (1) summary
      cd04458
      Location:90 → 155
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. XM_006522348.5 → XP_006522411.1  calcium-regulated heat stable protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3U434, Q3UD53
      Conserved Domains (1) summary
      cd04458
      Location:84 → 149
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    3. XM_006522346.4 → XP_006522409.2  calcium-regulated heat stable protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006522409.2

      UniProtKB/Swiss-Prot
      Q9CR86
      UniProtKB/TrEMBL
      Q3U434, Q3UD53, Q5M9P7
      Conserved Domains (1) summary
      cd04458
      Location:64 → 129
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR86.1 GenPept UniProtKB/Swiss-Prot:Q9CR86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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