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    Mcam melanoma cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 84004, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mcamprovided by MGI
    Official Full Name
    melanoma cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:1933966
    See related
    Ensembl:ENSMUSG00000032135 AllianceGenome:MGI:1933966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD146; CD149; Muc18; s-endo; 1-gicerin; s-gicerin
    Summary
    Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in external side of plasma membrane; extracellular space; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 97.6), lung adult (RPKM 73.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.1; 9 24.68 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44045958..44054024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44134658..44142727)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23954 Neighboring gene ring finger protein 26 Neighboring gene STARR-seq mESC enhancer starr_23955 Neighboring gene predicted gene 10687 Neighboring gene STARR-seq mESC enhancer starr_23959 Neighboring gene Casitas B-lineage lymphoma Neighboring gene STARR-positive B cell enhancer ABC_E5062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44046702-44046855 Neighboring gene coiled-coil domain containing 153

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway. Zhang ZY, et al. PLoS One, 2022. PMID 36001597, Free PMC Article
    2. Ectopic expression of MCAM/MUC18 increases in vitro motility and invasiveness, but decreases in vivo tumorigenesis and metastasis of a mouse melanoma K1735-9 subline in a syngeneic mouse model. Wu GJ. Clin Exp Metastasis, 2016 Dec. PMID 27510563
    3. Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform. Stalin J, et al. Cardiovasc Res, 2016 Aug 1. PMID 27170199
    4. Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow. Thomann S, et al. Oncotarget, 2015 Nov 24. PMID 26503468, Free PMC Article
    5. CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation. Jouve N, et al. Int J Cancer, 2015 Jul 1. PMID 25449773

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
      Title: CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
    2. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
      Title: Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling.
    3. CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
      Title: CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis.
    4. Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
      Title: Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
    5. Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
      Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
    6. CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
      Title: CD146 at the Interface between Oxidative Stress and the Wnt Signaling Pathway in Systemic Sclerosis.
    7. Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/beta-catenin pathway.
      Title: Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
    8. The CD146-HIF-1alpha axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
      Title: The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia.
    9. Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
      Title: Inhibition of CD146 attenuates retinal neovascularization via vascular endothelial growth factor receptor 2 signalling pathway in proliferative diabetic retinopathy.
    10. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
      Title: Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell surface glycoprotein MUC18
    Names
    gicerin
    l-gicerin protein
    melanoma adhesion molecule
    melanoma-associated antigen MUC18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359530.2 → NP_001346459.1  cell surface glycoprotein MUC18 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC148328
      Consensus CDS
      CCDS90545.1
      Related
      ENSMUSP00000096451.3, ENSMUST00000098852.3
      Conserved Domains (4) summary
      pfam08205
      Location:141 → 236
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:348 → 412
      Ig_3; Immunoglobulin domain
      cl11960
      Location:34 → 120
      Ig; Immunoglobulin domain
      cl28434
      Location:440 → 517
      I-set; Immunoglobulin I-set domain

    2. NM_001421323.1 → NP_001408252.1  cell surface glycoprotein MUC18 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC148328

    3. NM_023061.3 → NP_075548.2  cell surface glycoprotein MUC18 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075548.2

      Status: VALIDATED

      Source sequence(s)
      AC148328
      Consensus CDS
      CCDS23097.1
      UniProtKB/Swiss-Prot
      Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3
      Related
      ENSMUSP00000034650.9, ENSMUST00000034650.15
      Conserved Domains (5) summary
      smart00408
      Location:266 → 323
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:356 → 424
      IG_like; Immunoglobulin like
      pfam08205
      Location:141 → 236
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:351 → 427
      Ig_2; Immunoglobulin domain
      cl11960
      Location:452 → 509
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44045958..44054024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244742.2 → XP_030100602.1  cell surface glycoprotein MUC18 isoform X2

      Conserved Domains (4) summary
      smart00409
      Location:242 → 310
      IG; Immunoglobulin
      pfam08205
      Location:27 → 122
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:142 → 209
      Ig_3; Immunoglobulin domain
      cl11960
      Location:326 → 403
      Ig; Immunoglobulin domain

    2. XM_030244743.2 → XP_030100603.1  cell surface glycoprotein MUC18 isoform X3

      Conserved Domains (4) summary
      smart00409
      Location:242 → 310
      IG; Immunoglobulin
      pfam08205
      Location:27 → 122
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:142 → 209
      Ig_3; Immunoglobulin domain
      cl11960
      Location:326 → 403
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2Y2.1 GenPept UniProtKB/Swiss-Prot:Q8R2Y2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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