Dctpp1 dCTP pyrophosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctpp1provided by MGI
Official Full Name: dCTP pyrophosphatase 1provided by MGI
Primary source: MGI:MGI:1913672
See related: Ensembl:ENSMUSG00000042462 AllianceGenome:MGI:1913672
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RS21-C6; 2410015N17Rik
Summary: Enables several functions, including identical protein binding activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in nucleoside triphosphate catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; brain ventricular layer; lung; orbito-sphenoid; and vertebral axis musculature. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 40.4), liver E14.5 (RPKM 38.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.42 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126856131..126859839, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127256959..127260667, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Several key residues involved in the substrate binding of RS21-C6 have been identified.
Title: Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dCTP diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dCTP diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables pyrimidine deoxyribonucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA protection	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in dCTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dCTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dCTP pyrophosphatase 1

Names: XTP3-transactivated gene A protein homolog; dCTPase 1; deoxycytidine-triphosphatase 1

NP_075692.1

EC 3.6.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023203.1 → NP_075692.1 dCTP pyrophosphatase 1

See identical proteins and their annotated locations for NP_075692.1

Status: PROVISIONAL

Source sequence(s)

AF110764

Consensus CDS

CCDS21862.1

UniProtKB/Swiss-Prot

Q9QY93

Related

ENSMUSP00000047845.5, ENSMUST00000035276.5

Conserved Domains (1) summary

cd11537
Location:35 → 125

NTP-PPase_RS21-C6_like; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs