Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1gprovided by MGI
Official Full Name: protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoformprovided by MGI
Primary source: MGI:MGI:106065
See related: Ensembl:ENSMUSG00000029147 AllianceGenome:MGI:106065
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fin13
Summary: Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study schizophrenia. Orthologous to human PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 177.4), liver E14 (RPKM 82.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31360012..31377889, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31202668..31220545, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Title: PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Nuclear phosphatase PPM1G in cellular survival and neural development.
Title: Nuclear phosphatase PPM1G in cellular survival and neural development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppm1g (e-PCR), detects polymorphism
- UniSTS:143109

G54114 (e-PCR)
- UniSTS:109351

UniSTS:496035 (e-PCR)
- UniSTS:496035

Ppm1g (e-PCR), detects polymorphism
- UniSTS:496035

PPM1G_7857 (e-PCR)
- UniSTS:471724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cation binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1G

Names: PP2C-gamma; fibroblast growth factor inducible 13; fibroblast growth factor-inducible protein 13; protein phosphatase 1C; protein phosphatase magnesium-dependent 1 gamma

NP_032040.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008014.3 → NP_032040.1 protein phosphatase 1G

See identical proteins and their annotated locations for NP_032040.1

Status: PROVISIONAL

Source sequence(s)

AC114619

Consensus CDS

CCDS19179.1

UniProtKB/Swiss-Prot

Q61074

UniProtKB/TrEMBL

A0A0J9YVG0

Related

ENSMUSP00000031032.8, ENSMUST00000031032.11

Conserved Domains (2) summary

smart00332
Location:25 → 110

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:321 → 502

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...