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    Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16498, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kcnab2provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 2provided by MGI
    Primary source
    MGI:MGI:109239
    See related
    Ensembl:ENSMUSG00000028931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F5; I2r; Kcnb; I2rf5; Kcnb3; kv-beta-2
    Expression
    Biased expression in cortex adult (RPKM 40.8), frontal lobe adult (RPKM 32.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnab2 in Genome Data Viewer
    Location:
    4 E2; 4 83.08 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152475201..152562006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152390744..152477549, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (151764853..151851588, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene predicted gene 16333 Neighboring gene nephronophthisis 4 (juvenile) homolog (human) Neighboring gene predicted gene, 30734 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-threo-aldose 1-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aldo-keto reductase (NADP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aldo-keto reductase (NADP) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pinceau fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-gated potassium channel subunit beta-2
    Names
    K(+) channel subunit beta-2
    neuroimmune protein F5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252654.2NP_001239583.1  voltage-gated potassium channel subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_001239583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in coding region, compared to variant 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AI835117, AK143166, AL611985, CX224114
      Consensus CDS
      CCDS57316.1
      UniProtKB/TrEMBL
      Q3UPV6
      Related
      ENSMUSP00000030768.3, ENSMUST00000030768.10
      Conserved Domains (1) summary
      cd19141
      Location:25333
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    2. NM_001252655.2NP_001239584.1  voltage-gated potassium channel subunit beta-2 isoform 2

      See identical proteins and their annotated locations for NP_001239584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AI835117, AK143166, AL611985, BY232563, CK627448, CV784053, CX224114, CX768025
      Consensus CDS
      CCDS57316.1
      UniProtKB/TrEMBL
      Q3UPV6
      Related
      ENSMUSP00000124156.3, ENSMUST00000159840.8
      Conserved Domains (1) summary
      cd19141
      Location:25333
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    3. NM_001252656.2NP_001239585.1  voltage-gated potassium channel subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_001239585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AI835117, AK143166, AK152613, AL611985, CX224114
      Consensus CDS
      CCDS19000.1
      UniProtKB/Swiss-Prot
      P62482
      Related
      ENSMUSP00000101273.3, ENSMUST00000105648.10
      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    4. NM_001355172.1NP_001342101.1  voltage-gated potassium channel subunit beta-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AI835117, AK143166, AL611985, CK627448, CV784053, CX224114, CX768025, DN173203
      Consensus CDS
      CCDS19000.1
      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    5. NM_001355173.1NP_001342102.1  voltage-gated potassium channel subunit beta-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AI835117, AK143166, AL611985, BY198829, CK627448, CV784053, CX224114, CX768025, DN173203
      Related
      ENSMUSP00000158843.2, ENSMUST00000238738.2
      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    6. NM_010598.4NP_034728.2  voltage-gated potassium channel subunit beta-2 isoform 1

      See identical proteins and their annotated locations for NP_034728.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
      Source sequence(s)
      AI835117, AK143166, AL611985, BY198829, CK627448, CV784053, CX224114, CX768025, DN173203
      Consensus CDS
      CCDS19000.1
      UniProtKB/Swiss-Prot
      P62482
      Related
      ENSMUSP00000125058.2, ENSMUST00000160884.9
      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152475201..152562006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253266.1XP_030109126.1  voltage-gated potassium channel subunit beta-2 isoform X5

      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    2. XM_011250199.3XP_011248501.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_011248501.1

      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    3. XM_006538586.4XP_006538649.1  voltage-gated potassium channel subunit beta-2 isoform X4

      See identical proteins and their annotated locations for XP_006538649.1

      Conserved Domains (1) summary
      cd19141
      Location:25349
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    4. XM_030253267.1XP_030109127.1  voltage-gated potassium channel subunit beta-2 isoform X5

      Conserved Domains (1) summary
      cd19141
      Location:38347
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    5. XM_006538585.4XP_006538648.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_006538648.1

      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    6. XM_006538584.5XP_006538647.1  voltage-gated potassium channel subunit beta-2 isoform X3

      See identical proteins and their annotated locations for XP_006538647.1

      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    7. XM_006538587.5XP_006538650.1  voltage-gated potassium channel subunit beta-2 isoform X4

      See identical proteins and their annotated locations for XP_006538650.1

      Conserved Domains (1) summary
      cd19141
      Location:25349
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    8. XM_036163742.1XP_036019635.1  voltage-gated potassium channel subunit beta-2 isoform X3

      Conserved Domains (1) summary
      cd19141
      Location:38363
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    9. XM_011250198.3XP_011248500.1  voltage-gated potassium channel subunit beta-2 isoform X2

      Related
      ENSMUSP00000158771.2, ENSMUST00000238252.2
      Conserved Domains (1) summary
      cd19141
      Location:69378
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
    10. XM_011250197.4XP_011248499.1  voltage-gated potassium channel subunit beta-2 isoform X1

      Conserved Domains (1) summary
      cd19141
      Location:69394
      Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
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