Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnab2provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, beta member 2provided by MGI
Primary source: MGI:MGI:109239
See related: Ensembl:ENSMUSG00000028931 AllianceGenome:MGI:109239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: F5; I2rf5; Kcnb3; kv-beta-2
Summary: Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in neuromuscular process. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in axon and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and sensory organ. Used to study chromosome 1p36 deletion syndrome. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 40.8), frontal lobe adult (RPKM 32.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.08 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152475201..152561991, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (152390744..152477549, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potassium channel auxiliary subunit Kvbeta2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
Title: The potassium channel auxiliary subunit Kvβ2 (Kcnab2) regulates Kv1 channels and dopamine neuron firing.
Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvbeta Proteins.
Title: Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.
Kvbeta2 subunits regulate the expression of myocardial Kv channels and confer redox sensitivity to Kv current and cardiac repolarization.
Title: Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.
Genetic deletion of Kvbeta2 leads to decreased skeletal muscle size along with isotype switching from fast to slow fiber type.
Title: Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
Article reports a newly identified protein-protein interaction between the postsynaptic density-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
the association of a Kvbeta subunit with TRPV1 channels, is reported.
Title: Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).
This study demonistrated that loss of Kvbeta2 likely contributes to the cognitive and neurological impairments observed in 1p36DS patients.
Title: Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability.
strain differences significantly affected survival, body weight and thermoregulation in Kv beta2-null mice
Title: Genetic modifiers of the Kv beta2-null phenotype in mice.
investigation of in vivo function
Title: Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2).

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225032

Kcnab2 (e-PCR), detects polymorphism
- UniSTS:143654

Kcnab2 (e-PCR), detects polymorphism
- UniSTS:143655

RH138171 (e-PCR)
- UniSTS:220258

U31908 (e-PCR)
- UniSTS:159333

D4Mit356 (e-PCR), detects polymorphism
- UniSTS:130151

RH94672 (e-PCR)
- UniSTS:119919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in pinceau fiber	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-2

Names: K(+) channel subunit beta-2; neuroimmune protein F5

NP_001239583.1

EC 1.1.1.-

NP_001239584.1

EC 1.1.1.-

NP_001239585.1

EC 1.1.1.-

NP_001342101.1

EC 1.1.1.-

NP_001342102.1

EC 1.1.1.-

NP_001408146.1

EC 1.1.1.-

NP_001408147.1

EC 1.1.1.-

NP_001408148.1

EC 1.1.1.-

NP_001408150.1

EC 1.1.1.-

NP_001408151.1

EC 1.1.1.-

NP_001408152.1

EC 1.1.1.-

NP_001408153.1

EC 1.1.1.-

NP_001408154.1

EC 1.1.1.-

NP_034728.2

EC 1.1.1.-

XP_006538647.1

EC 1.1.1.-

XP_006538648.1

EC 1.1.1.-

XP_006538649.1

EC 1.1.1.-

XP_006538650.1

EC 1.1.1.-

XP_011248501.1

EC 1.1.1.-

XP_030109127.1

EC 1.1.1.-

XP_036019635.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252654.3 → NP_001239583.1 voltage-gated potassium channel subunit beta-2 isoform 2

See identical proteins and their annotated locations for NP_001239583.1

Status: VALIDATED

Source sequence(s)

AL611985

Consensus CDS

CCDS57316.1

UniProtKB/TrEMBL

Q3U0B0, Q3UPV6

Related

ENSMUSP00000030768.3, ENSMUST00000030768.10

Conserved Domains (1) summary

cd19141
Location:25 → 333

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
NM_001252655.3 → NP_001239584.1 voltage-gated potassium channel subunit beta-2 isoform 2

See identical proteins and their annotated locations for NP_001239584.1

Status: VALIDATED

Source sequence(s)

AL611985

Consensus CDS

CCDS57316.1

UniProtKB/TrEMBL

Q3U0B0, Q3UPV6

Related

ENSMUSP00000124156.3, ENSMUST00000159840.8

Conserved Domains (1) summary

cd19141
Location:25 → 333

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
NM_001252656.3 → NP_001239585.1 voltage-gated potassium channel subunit beta-2 isoform 1

See identical proteins and their annotated locations for NP_001239585.1

Status: VALIDATED

Source sequence(s)

AL611985

Consensus CDS

CCDS19000.1

UniProtKB/Swiss-Prot

P62482, P97381, Q60942, Q64284

UniProtKB/TrEMBL

Q3U0B0

Related

ENSMUSP00000101273.3, ENSMUST00000105648.10

Conserved Domains (1) summary

cd19141
Location:38 → 347

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
NM_001355172.1 → NP_001342101.1 voltage-gated potassium channel subunit beta-2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).

Source sequence(s)

AI835117, AK143166, AL611985, CK627448, CV784053, CX224114, CX768025, DN173203

Consensus CDS

CCDS19000.1

UniProtKB/Swiss-Prot

P62482, P97381, Q60942, Q64284

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 347

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
NM_001355173.2 → NP_001342102.1 voltage-gated potassium channel subunit beta-2 isoform 3

Status: VALIDATED

Source sequence(s)

AL611985

UniProtKB/TrEMBL

Q3U0B0

Related

ENSMUSP00000158843.2, ENSMUST00000238738.2

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
NM_001421217.1 → NP_001408146.1 voltage-gated potassium channel subunit beta-2 isoform 1

Status: VALIDATED

Source sequence(s)

AL611985

UniProtKB/Swiss-Prot

P62482, P97381, Q60942, Q64284
NM_001421218.1 → NP_001408147.1 voltage-gated potassium channel subunit beta-2 isoform 3

Status: VALIDATED

Source sequence(s)

AL611985
NM_001421219.1 → NP_001408148.1 voltage-gated potassium channel subunit beta-2 isoform 4

Status: VALIDATED

Source sequence(s)

AL611985
NM_001421221.1 → NP_001408150.1 voltage-gated potassium channel subunit beta-2 isoform 5

Status: VALIDATED

Source sequence(s)

AL611985
NM_001421222.1 → NP_001408151.1 voltage-gated potassium channel subunit beta-2 isoform 5

Status: VALIDATED

Source sequence(s)

AL611985
NM_001421223.1 → NP_001408152.1 voltage-gated potassium channel subunit beta-2 isoform 6

Status: VALIDATED

Source sequence(s)

AL611985

UniProtKB/TrEMBL

A0A571BF54
NM_001421224.1 → NP_001408153.1 voltage-gated potassium channel subunit beta-2 isoform 7

Status: VALIDATED

Source sequence(s)

AL611985
NM_001421225.1 → NP_001408154.1 voltage-gated potassium channel subunit beta-2 isoform 8

Status: VALIDATED

Source sequence(s)

AL611985

UniProtKB/TrEMBL

E0CXZ9
NM_010598.5 → NP_034728.2 voltage-gated potassium channel subunit beta-2 isoform 1

See identical proteins and their annotated locations for NP_034728.2

Status: VALIDATED

Source sequence(s)

AL611985

Consensus CDS

CCDS19000.1

UniProtKB/Swiss-Prot

P62482, P97381, Q60942, Q64284

UniProtKB/TrEMBL

Q3U0B0

Related

ENSMUSP00000125058.2, ENSMUST00000160884.9

Conserved Domains (1) summary

cd19141
Location:38 → 347

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

152475201..152561991 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250199.3 → XP_011248501.1 voltage-gated potassium channel subunit beta-2 isoform X3

See identical proteins and their annotated locations for XP_011248501.1

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_006538586.4 → XP_006538649.1 voltage-gated potassium channel subunit beta-2 isoform X4

See identical proteins and their annotated locations for XP_006538649.1

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:25 → 349

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_030253267.1 → XP_030109127.1 voltage-gated potassium channel subunit beta-2 isoform X5

UniProtKB/Swiss-Prot

P62482, P97381, Q60942, Q64284

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 347

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_006538585.4 → XP_006538648.1 voltage-gated potassium channel subunit beta-2 isoform X3

See identical proteins and their annotated locations for XP_006538648.1

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_006538584.5 → XP_006538647.1 voltage-gated potassium channel subunit beta-2 isoform X3

See identical proteins and their annotated locations for XP_006538647.1

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_006538587.5 → XP_006538650.1 voltage-gated potassium channel subunit beta-2 isoform X4

See identical proteins and their annotated locations for XP_006538650.1

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:25 → 349

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_036163742.1 → XP_036019635.1 voltage-gated potassium channel subunit beta-2 isoform X3

UniProtKB/TrEMBL

Q3U0B0

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)