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    Lztfl1 leucine zipper transcription factor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 93730, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lztfl1provided by MGI
    Official Full Name
    leucine zipper transcription factor-like 1provided by MGI
    Primary source
    MGI:MGI:1934860
    See related
    Ensembl:ENSMUSG00000025245 AllianceGenome:MGI:1934860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5530402H04Rik; 6130400H19Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of protein localization to ciliary membrane. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Biedl syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F4; 9 74.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123523469..123546690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123694404..123717625, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 20A Neighboring gene STARR-seq mESC enhancer starr_25570 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626087-123626387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626696-123626997 Neighboring gene STARR-seq mESC enhancer starr_25571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123663531-123663880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123665948-123666172 Neighboring gene predicted gene 17021 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123693813-123694114 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain containing 1 Neighboring gene C-X-C motif chemokine receptor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice. Jiang J, et al. J Genet Genomics, 2016 Jun 20. PMID 27312011, Free PMC Article
    2. Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training. Sakurai T, et al. Biochem Biophys Res Commun, 2011 Dec 9. PMID 22093827
    3. Limited time window for retinal gene therapy in a preclinical model of ciliopathy. Datta P, et al. Hum Mol Genet, 2020 Aug 11. PMID 32568387, Free PMC Article
    4. Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. Wei Q, et al. J Mol Cell Biol, 2018 Oct 1. PMID 30423168, Free PMC Article
    5. LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin. Wang L, et al. J Cancer Res Clin Oncol, 2014 Dec. PMID 25005785

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
      Title: Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
    2. Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.
      Title: Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.
    3. Limited time window for retinal gene therapy in a preclinical model of ciliopathy.
      Title: Limited time window for retinal gene therapy in a preclinical model of ciliopathy.
    4. Lztfl1 is required for leptin signaling in the hypothalamus.Lztfl1 functions downstream of leptin receptor in regulation of actin/cytoskeleton dynamics.
      Title: Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons.
    5. LZTFL1 is a cilium protein and regulates animal weight and photoreceptor connecting cilium function probably by controlling microtubule assembly and protein trafficking in cilia
      Title: Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice.
    6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling
      Title: A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
    7. the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training.
      Title: Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106871

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper transcription factor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033322.3 → NP_201579.1  leucine zipper transcription factor-like protein 1

      See identical proteins and their annotated locations for NP_201579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) reprsents the protein-coding variant.
      Source sequence(s)
      AK054003, AK147312, BE979461
      Consensus CDS
      CCDS40818.1
      UniProtKB/Swiss-Prot
      Q8BRX8, Q8CDS2, Q9JHQ5
      UniProtKB/TrEMBL
      Q8CDG8
      Related
      ENSMUSP00000026274.8, ENSMUST00000026274.14
      Conserved Domains (1) summary
      pfam15294
      Location:20 → 294
      Leu_zip; Leucine zipper

    RNA

    1. NR_151689.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK147312, BE979461
      Related
      ENSMUST00000165754.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123523469..123546690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512403.5 → XP_006512466.1  leucine zipper transcription factor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8CDG8
      Related
      ENSMUSP00000132359.2, ENSMUST00000168921.2
      Conserved Domains (1) summary
      pfam15294
      Location:3 → 277
      Leu_zip; Leucine zipper
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHQ5.1 GenPept UniProtKB/Swiss-Prot:Q9JHQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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