Cd248 CD248 antigen, endosialin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd248provided by MGI
Official Full Name: CD248 antigen, endosialinprovided by MGI
Primary source: MGI:MGI:1917695
See related: Ensembl:ENSMUSG00000056481 AllianceGenome:MGI:1917695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tem1; Cd164l1; 2610111G01Rik
Summary: Enables extracellular matrix binding activity. Acts upstream of or within several processes, including anatomical structure regression; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.24 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5118106..5120668)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5068078..5070640)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
Title: IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-beta activity through its receptor stability in dermal fibroblasts.
Title: TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.
Title: CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.
Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8[+] T cells in clear cell renal cell carcinoma.
Title: Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8(+) T cells in clear cell renal cell carcinoma.
Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome.
Title: Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome.
CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.
Title: CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.
CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer.
Title: CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer.
Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling.
Title: Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling.
Efficacy of piperacillin-tazobactam and cefotaxime against Escherichia coli hyperproducing TEM-1 in a mouse peritonitis infection model.
Title: Efficacy of piperacillin-tazobactam and cefotaxime against Escherichia coli hyperproducing TEM-1 in a mouse peritonitis infection model.
Metabolic consequences for mice lacking Endosialin: LC-MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock-out mice.
Title: Metabolic consequences for mice lacking Endosialin: LC-MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock-out mice.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI842296 (e-PCR)
- UniSTS:164646

Tem1-pending (e-PCR), detects polymorphism
- UniSTS:259153

RH143922 (e-PCR)
- UniSTS:233168

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: endosialin

Names: CD164 sialomucin-like 1; tumor endothelial marker 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054042.2 → NP_473383.1 endosialin precursor

See identical proteins and their annotated locations for NP_473383.1

Status: VALIDATED

Source sequence(s)

BC046318

Consensus CDS

CCDS29448.1

UniProtKB/Swiss-Prot

Q3UMV6, Q91V98, Q91ZV1

UniProtKB/TrEMBL

A0A172Q386

Related

ENSMUSP00000070847.7, ENSMUST00000070630.8

Conserved Domains (4) summary

cd03600
Location:29 → 160

CLECT_thrombomodulin_like; C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR

smart00179
Location:312 → 350

EGF_CA; Calcium-binding EGF-like domain

pfam01826
Location:269 → 316

TIL; Trypsin Inhibitor like cysteine rich domain

pfam14670
Location:235 → 271

FXa_inhibition; Coagulation Factor Xa inhibitory site