Itgb5 integrin beta 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb5provided by MGI
Official Full Name: integrin beta 5provided by MGI
Primary source: MGI:MGI:96614
See related: Ensembl:ENSMUSG00000022817 AllianceGenome:MGI:96614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: [b]5; [b]-5; [b]5A; [b]5B; beta5; ESTM23; beta-5
Summary: Enables integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge; focal adhesion; and glutamatergic synapse. Is integral component of synaptic membrane. Part of integrin alphav-beta5 complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 97.5), ovary adult (RPKM 81.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 24.22 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (33650021..33769708)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (33829665..33949338)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin beta5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy.
Title: Integrin β5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy.
PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin.
Title: PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease.
Title: Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's Disease.
Autoregulation of insulin receptor signaling through MFGE8 and the alphavbeta5 integrin.
Title: Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Tumor-penetrating therapy for beta5 integrin-rich pancreas cancer.
Title: Tumor-penetrating therapy for β5 integrin-rich pancreas cancer.
mice lacking alphavbeta5 on haematopoietic cells show increased susceptibility to chemical colitis and we conclude that alphavbeta5 contributes to the tissue repair by regulating the homeostatic properties of intestinal macrophages
Title: Expression and characterization of αvβ5 integrin on intestinal macrophages.
Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3/FAK/AKT signaling pathway.
Title: Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM.
Title: Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.
Knock-in mice expressing a CCN1 mutant that is unable to bind alphavbeta5/alphavbeta3 were impaired in ductular reaction. CCN1, acting through its alphav beta3/alphav beta5 binding site, is critical for survival after bile duct ligation.
Title: CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.
Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration
Title: FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA475909 (e-PCR), detects polymorphism
- UniSTS:143009

AF022110 (e-PCR)
- UniSTS:163570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
part_of integrin alphav-beta5 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta5 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: integrin beta-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145884.2 → NP_001139356.1 integrin beta-5 isoform 1 precursor

See identical proteins and their annotated locations for NP_001139356.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AC155268, AC165079

Consensus CDS

CCDS49835.1

UniProtKB/Swiss-Prot

O70308, O70309, O88347

UniProtKB/TrEMBL

Q6PE70

Related

ENSMUSP00000110680.4, ENSMUST00000115028.11

Conserved Domains (3) summary

pfam00362
Location:35 → 463

Integrin_beta; Integrin, beta chain

pfam07965
Location:635 → 718

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:745 → 788

Integrin_b_cyt; Integrin beta cytoplasmic domain
NM_001405063.1 → NP_001391992.1 integrin beta-5 isoform 3

Status: VALIDATED

Source sequence(s)

AC155268, AC165079

UniProtKB/TrEMBL

A0A338P795

Related

ENSMUSP00000156332.2, ENSMUST00000232262.2
NM_010580.3 → NP_034710.2 integrin beta-5 isoform 2 precursor

See identical proteins and their annotated locations for NP_034710.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, translation termination at a downstream stop codon, and a longer isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC155268, AC165079

Consensus CDS

CCDS28135.1

UniProtKB/Swiss-Prot

O70308, O70309, O88347

UniProtKB/TrEMBL

G5E8F8

Related

ENSMUSP00000069416.6, ENSMUST00000069345.6

Conserved Domains (3) summary

pfam00362
Location:35 → 463

Integrin_beta; Integrin, beta chain

pfam07965
Location:635 → 718

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:745 → 759

Integrin_b_cyt; Integrin beta cytoplasmic domain