Ilf2 interleukin enhancer binding factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ilf2provided by MGI
Official Full Name: interleukin enhancer binding factor 2provided by MGI
Primary source: MGI:MGI:1915031
See related: Ensembl:ENSMUSG00000001016 AllianceGenome:MGI:1915031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tex261; Tex267; TEG-267; 6230405A16Rik
Summary: Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Located in nucleolus. Is expressed in several structures, including brain; early conceptus; ganglia; gonad; and incisor. Orthologous to human ILF2 (interleukin enhancer binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 75.1), CNS E14 (RPKM 54.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.23 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90383421..90395686)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90476201..90488379)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues.
Title: NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.
NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo.
Title: Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.
we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors.
Title: NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription.
Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin
Title: Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH125753 (e-PCR)
- UniSTS:162506

AV026596 (e-PCR)
- UniSTS:185553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin enhancer-binding factor 2

Names: nuclear factor of activated T-cells 45 kDa; testis expressed gene 267

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026374.3 → NP_080650.1 interleukin enhancer-binding factor 2

See identical proteins and their annotated locations for NP_080650.1

Status: PROVISIONAL

Source sequence(s)

AC160552

Consensus CDS

CCDS17530.1

UniProtKB/Swiss-Prot

Q3U083, Q5RKG0, Q8CCY9, Q99KS3, Q9CXY6

UniProtKB/TrEMBL

Q3UXI9

Related

ENSMUSP00000001042.9, ENSMUST00000001042.10

Conserved Domains (1) summary

smart00572
Location:98 → 338

DZF; domain in DSRM or ZnF_C2H2 domain containing proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90383421..90395686

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163253.1 → XP_036019146.1 interleukin enhancer-binding factor 2 isoform X1

Conserved Domains (1) summary

cl02675
Location:1 → 182

DZF; DZF domain