Epb41l4b erythrocyte membrane protein band 4.1 like 4b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epb41l4bprovided by MGI
Official Full Name: erythrocyte membrane protein band 4.1 like 4bprovided by MGI
Primary source: MGI:MGI:1859149
See related: Ensembl:ENSMUSG00000028434 AllianceGenome:MGI:1859149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ehm2; Lulu2; Epb4.1l4b; D4Ertd346e; 6430543G08Rik
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Is expressed in several structures, including cartilage; genitourinary system; gut; nervous system; and skin. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 21.1), colon adult (RPKM 11.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (56991977..57143753, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (56991972..57143168, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125019 (e-PCR)
- UniSTS:161841

Epb4.1l4b (e-PCR), detects polymorphism
- UniSTS:164919

RH126980 (e-PCR)
- UniSTS:167388

RH127012 (e-PCR)
- UniSTS:167389

MARC_21252-21253:1032892750:1 (e-PCR)
- UniSTS:268517

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: band 4.1-like protein 4B

Names: erythrocyte protein band 4.1-like 4b; erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells; expressed in high-metastatic cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355492.2 → NP_001342421.1 band 4.1-like protein 4B isoform 2

Status: VALIDATED

Source sequence(s)

AL805921, AL831761

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)
NM_001424796.1 → NP_001411725.1 band 4.1-like protein 4B isoform 3

Status: VALIDATED

Source sequence(s)

AL805921, AL831761
NM_019427.3 → NP_062300.2 band 4.1-like protein 4B isoform 1

See identical proteins and their annotated locations for NP_062300.2

Status: VALIDATED

Source sequence(s)

AL805921, AL831761

Consensus CDS

CCDS51180.1

UniProtKB/Swiss-Prot

A2ALK7, Q9JMC8

UniProtKB/TrEMBL

Q3TMR3

Related

ENSMUSP00000030142.4, ENSMUST00000030142.4

Conserved Domains (5) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:170 → 277

FERM_M; FERM central domain

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)

pfam09379
Location:89 → 151

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

56991977..57143753 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164240.1 → XP_036020133.1 band 4.1-like protein 4B isoform X5

Conserved Domains (2) summary

pfam08736
Location:78 → 119

FA; FERM adjacent (FA)

cl17171
Location:10 → 65

PH-like; Pleckstrin homology-like domain
XM_011250068.2 → XP_011248370.1 band 4.1-like protein 4B isoform X2

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)
XM_006538087.4 → XP_006538150.1 band 4.1-like protein 4B isoform X1

UniProtKB/TrEMBL

A2ALK6

Related

ENSMUSP00000092687.4, ENSMUST00000095076.10

Conserved Domains (3) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)
XM_006538089.5 → XP_006538152.1 band 4.1-like protein 4B isoform X4

Conserved Domains (4) summary

smart00295
Location:87 → 277

B41; Band 4.1 homologues

pfam06495
Location:332 → 498

Transformer; Fruit fly transformer protein

cd13186
Location:273 → 366

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam08736
Location:379 → 419

FA; FERM adjacent (FA)