Fzd2 frizzled class receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd2provided by MGI
Official Full Name: frizzled class receptor 2provided by MGI
Primary source: MGI:MGI:1888513
See related: Ensembl:ENSMUSG00000050288 AllianceGenome:MGI:1888513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz10; Fzd10; Mfz10; Mfz10a
Summary: Enables Wnt-activated receptor activity. Acts upstream of or within several processes, including animal organ morphogenesis; hard palate development; and nervous system development. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102495257..102498884)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102604431..102608058)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Wnt5a/Frizzled-2 axis suppresses beta-catenin signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclusion of the liver regeneration process
Title: WNT5A inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration.
Fzd2 promotes changes in epithelial cell length and shape. These changes in cell morphology deform the developing lung epithelial tube to generate and maintain new domain branches.
Title: Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape.
Results provide further insight into the role of Wnt5a and Fzd2 in the pathogenesis of adult amyotrophic lateral sclerosis transgenic mice.
Title: Expression of Wnt5a and its receptor Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice.
observed genetic interactions between Fz2 and Fz7 and five canonical and/or non-canonical signaling molecules: Dvl3, Wnt3a, Wnt11, Vangl2, and Wnt5a.
Title: Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.
Frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies.
Title: Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.
Indicate that myofibroblast migration and differentiation are modulated via Wnt/Fzd signalling.
Title: Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.
Preferential expression of Frizzled2 gene is detected in fetal liver kinase (Flk)1-negative and Flk1-positive cells under different culture conditions.
Title: Differential expression of the Wnt and Frizzled genes in Flk1+ cells derived from mouse ES cells.
Protein kinase G is a critical downstream effector of the noncanonical Wnt-Frizzled-2/cGMP/Ca2+ pathway
Title: Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd2 (e-PCR), detects polymorphism
- UniSTS:532232

RH66817 (e-PCR)
- UniSTS:31831

AW456835 (e-PCR)
- UniSTS:180337

Fzd1 (e-PCR), detects polymorphism
- UniSTS:495987

Fzd2 (e-PCR), detects polymorphism
- UniSTS:516475

UniSTS:236739 (e-PCR)
- UniSTS:236739

Fzd2 (e-PCR), detects polymorphism
- UniSTS:508385

Fzd2 (e-PCR), detects polymorphism
- UniSTS:508386

NoName (e-PCR)
- UniSTS:548579

RH124188 (e-PCR)
- UniSTS:161010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, calcium modulating pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endothelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hard palate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hard palate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within membranous septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: frizzled-2

Names: frizzled homolog 2; frizzled-10; fz-10; fz-2; mFz2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020510.2 → NP_065256.1 frizzled-2 precursor

See identical proteins and their annotated locations for NP_065256.1

Status: VALIDATED

Source sequence(s)

AL672269, BC055727, CB527017

Consensus CDS

CCDS25501.1

UniProtKB/Swiss-Prot

Q810M0, Q9JIP5, Q9JIP6, Q9WUJ2

Related

ENSMUSP00000091463.5, ENSMUST00000057893.7

Conserved Domains (2) summary

cd07464
Location:40 → 166

CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor

pfam01534
Location:240 → 557

Frizzled; Frizzled/Smoothened family membrane region