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    Txnl4a thioredoxin-like 4A [ Mus musculus (house mouse) ]

    Gene ID: 27366, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Txnl4aprovided by MGI
    Official Full Name
    thioredoxin-like 4Aprovided by MGI
    Primary source
    MGI:MGI:1351613
    See related
    Ensembl:ENSMUSG00000057130 AllianceGenome:MGI:1351613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dim1; Txnl4; U5-15kD; U5-15kDa; D18Wsu98e
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Is expressed in several structures, including brain ventricular layer; submandibular gland primordium; thymus primordium; tooth; and trigeminal ganglion. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 29.5), CNS E11.5 (RPKM 21.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E3; 18 53.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80250041..80269066)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80206826..80225851)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosome binding factor A, opposite strand Neighboring gene predicted gene, 46629 Neighboring gene STARR-positive B cell enhancer ABC_E5666 Neighboring gene ribosome binding factor A Neighboring gene N(alpha)-acetyltransferase 12, NatA catalytic subunit Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2 Neighboring gene STARR-seq mESC enhancer starr_45175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein. Reuter K, et al. J Mol Biol, 1999 Nov 26. PMID 10610776
    2. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of U5 snRNP TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-like protein 4A
    Names
    DIM1 protein homolog
    spliceosomal U5 snRNP-specific 15 kDa protein
    thioredoxin-like 4
    thioredoxin-like U5 snRNP protein U5-15kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038608.3 → NP_001033697.2  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_001033697.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding exons and 3' UTR compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001042408.2 → NP_001035867.1  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_001035867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001384173.1 → NP_001371102.1  thioredoxin-like protein 4A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1 and 6, encodes isoform a.
      Source sequence(s)
      AC131065
      UniProtKB/Swiss-Prot
      P83877, Q3TLI3
      Conserved Domains (1) summary
      PLN00410
      Location:1 → 142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional

    4. NM_001384174.1 → NP_001371103.1  thioredoxin-like protein 4A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1 and 5, encodes isoform a.
      Source sequence(s)
      AC131065
      UniProtKB/Swiss-Prot
      P83877, Q3TLI3
      Conserved Domains (1) summary
      PLN00410
      Location:1 → 142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional

    5. NM_001384175.1 → NP_001371104.1  thioredoxin-like protein 4A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    6. NM_001384176.1 → NP_001371105.1  thioredoxin-like protein 4A isoform d

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    7. NM_001384177.1 → NP_001371106.1  thioredoxin-like protein 4A isoform e

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    8. NM_025299.4 → NP_079575.1  thioredoxin-like protein 4A isoform a

      See identical proteins and their annotated locations for NP_079575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC131065
      Consensus CDS
      CCDS29365.1
      UniProtKB/Swiss-Prot
      P83877, Q3TLI3
      Related
      ENSMUSP00000115320.2, ENSMUST00000145963.9
      Conserved Domains (1) summary
      PLN00410
      Location:1 → 142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional

    9. NM_178604.4 → NP_848719.2  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_848719.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7
      Conserved Domains (1) summary
      cl00388
      Location:1 → 51
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_168913.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065

    2. NR_168914.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065

    3. NR_168915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80250041..80269066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042409.1: Suppressed sequence

      Description
      NM_001042409.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83877.1 GenPept UniProtKB/Swiss-Prot:P83877

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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