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    Serinc4 serine incorporator 4 [ Mus musculus (house mouse) ]

    Gene ID: 574418, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Serinc4provided by MGI
    Official Full Name
    serine incorporator 4provided by MGI
    Primary source
    MGI:MGI:2441842
    See related
    Ensembl:ENSMUSG00000046110 AllianceGenome:MGI:2441842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930015D22Rik
    Summary
    Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SERINC4 (serine incorporator 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 75.9), large intestine adult (RPKM 55.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 60.39 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121281658..121287245, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121451177..121456764, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene small EDRK-rich factor 2 Neighboring gene huntingtin interacting protein K Neighboring gene microfibrillar-associated protein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. Inuzuka M, et al. J Biol Chem, 2005 Oct 21. PMID 16120614
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine incorporator 4
    Names
    ortholog of serine incorporator 4 SERINC4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025371.2 → NP_001020542.1  serine incorporator 4 isoform 1

      See identical proteins and their annotated locations for NP_001020542.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC083132
      Consensus CDS
      CCDS16646.1
      UniProtKB/Swiss-Prot
      Q5XK03, Q8C8U1
      Related
      ENSMUSP00000051261.4, ENSMUST00000056312.10
      Conserved Domains (1) summary
      pfam03348
      Location:36 → 471
      Serinc; Serine incorporator (Serinc)

    2. NM_001363097.1 → NP_001350026.1  serine incorporator 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL845466, BC026459
      Consensus CDS
      CCDS89545.1
      UniProtKB/TrEMBL
      A2ARQ6
      Related
      ENSMUSP00000106243.3, ENSMUST00000110613.9
      Conserved Domains (1) summary
      pfam03348
      Location:35 → 276
      Serinc; Serine incorporator (Serinc)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121281658..121287245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319149.3 → XP_017174638.1  serine incorporator 4 isoform X1

      Conserved Domains (1) summary
      pfam03348
      Location:32 → 232
      Serinc; Serine incorporator (Serinc)

    RNA

    1. XR_001783158.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XK03.1 GenPept UniProtKB/Swiss-Prot:Q5XK03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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