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    Eral1 Era like 12S mitochondrial rRNA chaperone 1 [ Mus musculus (house mouse) ]

    Gene ID: 57837, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eral1provided by MGI
    Official Full Name
    Era like 12S mitochondrial rRNA chaperone 1provided by MGI
    Primary source
    MGI:MGI:1889295
    See related
    Ensembl:ENSMUSG00000020832 AllianceGenome:MGI:1889295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Era; M-ERA; MERA-S; MERA-W; 2610524P08Rik; 9130407C09Rik
    Summary
    Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in ribosomal small subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol and mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in ureter and urinary system. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.4), mammary gland adult (RPKM 17.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77964202..77971209, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78073376..78080383, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57805 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144 Neighboring gene family with sequence similarity 222, member B Neighboring gene STARR-seq mESC enhancer starr_30086 Neighboring gene U6 small nuclear RNA associated LSM6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10694 Neighboring gene STARR-seq mESC enhancer starr_30088 Neighboring gene TNF receptor associated factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Li S, et al. Cell Rep, 2021 Jan 19. PMID 33472079
    2. Global Proteome of LonP1(+/-) Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes. Key J, et al. Int J Mol Sci, 2019 Sep 12. PMID 31547314, Free PMC Article
    3. CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. Szczepanowska K, et al. EMBO J, 2016 Dec 1. PMID 27797820, Free PMC Article
    4. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. Britton RA, et al. Genomics, 2000 Jul 1. PMID 10945472
    5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of membrane estrogen receptor alpha (ERalpha) in the rapid regulation of male sexual behavior.
      Title: Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior.
    2. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
      Title: The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
    3. LonP1(+/-) mouse embryonal fibroblasts also showed Eral1 accumulation, but no systematic effect on mitoribosomal subunits.
      Title: Global Proteome of LonP1(+/-) Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.
    4. The authors show that the defect in mitoribosomal assembly is a consequence of the accumulation of ERAL1, a putative 12S rRNA chaperone, and novel ClpXP substrate.
      Title: CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTPase Era, mitochondrial
    Names
    CEGA
    ERA-W
    ERA-like GTPase
    ERA-like protein 1
    GTP-binding protein era homolog
    conserved ERA-like GTPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022313.2 → NP_071708.2  GTPase Era, mitochondrial

      See identical proteins and their annotated locations for NP_071708.2

      Status: VALIDATED

      Source sequence(s)
      AF190730, AK012155, BY158323
      Consensus CDS
      CCDS48856.1
      UniProtKB/Swiss-Prot
      Q6NV78, Q8VE60, Q925U1, Q9CZU4
      Related
      ENSMUSP00000021183.4, ENSMUST00000021183.4
      Conserved Domains (3) summary
      cd04163
      Location:111 → 327
      Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
      COG1159
      Location:108 → 437
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
      pfam07650
      Location:363 → 431
      KH_2; KH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77964202..77971209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZU4.1 GenPept UniProtKB/Swiss-Prot:Q9CZU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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