Slurp1 secreted Ly6/Plaur domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slurp1provided by MGI
Official Full Name: secreted Ly6/Plaur domain containing 1provided by MGI
Primary source: MGI:MGI:1930923
See related: Ensembl:ENSMUSG00000022596 AllianceGenome:MGI:1930923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARS; ArsB; Slurp-1; 1110021N19Rik
Summary: Predicted to enable acetylcholine receptor activator activity. Acts upstream of or within several processes, including negative regulation of cell migration; negative regulation of keratinocyte proliferation; and neuromuscular process controlling posture. Predicted to be located in extracellular space. Is expressed in cornea. Used to study mal de Meleda. Human ortholog(s) of this gene implicated in mal de Meleda and palmoplantar keratosis. Orthologous to human SLURP1 (secreted LY6/PLAUR domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 162.8) and lung adult (RPKM 23.1) See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.26 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74598493..74599872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74726644..74728023, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression.
Title: Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression.
Endogenous alpha7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier.
Title: Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier.
New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice.
Title: New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice.
Both Slurp1-/- and Slurp1-/-; Slurp2-/- mice, which were created and maintained on an inbred background, developed hind-limb clasping. These studies indicate that this phenotype, typically found in the setting of neuropathy and other forms of neurological disease, is a bona fide phenotype of Slurp1 deficiency.
Title: Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice.
The hypomorphic Egfr allele, which leads to reduced EGFR signalling in keratinocytes, did not ameliorate the PPK elicited by SLURP1 deficiency, suggesting that SLURP1 deficiency causes PPK independently (or downstream) from the EGFR pathway.
Title: A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency.
SLURP1 participates in pathophysiology of psoriasis by regulating keratinocyte proliferation and differentiation, and by suppressing the growth of S. aureus
Title: IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus.
SLURP1 nonsense mutation is responsible for the pathogenesis of palmoplantar keratoderma.
Title: Palmoplantar Keratoderma in Slurp2-Deficient Mice.
These data describe the influence of age, sex, genetic background, and ocular surface health on mouse corneal expression of Slurp1, establish the baseline for human tear SLURP1 expression.
Title: Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health.
Slurp1 in mice has a role in neuromuscular and metabolic phenotypes in addition to its role in palmoplantar keratoderma
Title: Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.
Those findings suggest that diminished expression of SLURP-1 in asthma attenuates its negative regulation of airway inflammation, and that perhaps changes in SLURP-1 expression could serve as a marker of airway damage in asthma.
Title: Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

AI415082 (e-PCR)
- UniSTS:180772

NoName (e-PCR)
- UniSTS:487869

AJ132356 (e-PCR)
- UniSTS:163558

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor activator activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urokinase plasminogen activator signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secreted Ly-6/uPAR-related protein 1

Names: Ars component B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020519.2 → NP_065265.1 secreted Ly-6/uPAR-related protein 1 precursor

See identical proteins and their annotated locations for NP_065265.1

Status: VALIDATED

Source sequence(s)

AK003904, BY704159

Consensus CDS

CCDS27528.1

UniProtKB/Swiss-Prot

Q2TA55, Q9Z0K7

Related

ENSMUSP00000141013.2, ENSMUST00000190433.2

Conserved Domains (1) summary

cd00117
Location:24 → 102

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...