Lipg lipase, endothelial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lipgprovided by MGI
Official Full Name: lipase, endothelialprovided by MGI
Primary source: MGI:MGI:1341803
See related: Ensembl:ENSMUSG00000053846 AllianceGenome:MGI:1341803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EL; mEDL; lipase; 3110013K01Rik
Summary: Enables phospholipase activity. Acts upstream of or within regulation of lipoprotein metabolic process. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiovascular system disease; cerebral infarction; coronary artery disease; and myocardial infarction. Orthologous to human LIPG (lipase G, endothelial type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 41.5), ovary adult (RPKM 21.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 50.94 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (75072393..75095380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (74939322..74961263, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional involvement of endothelial lipase in hepatitis B virus infection.
Title: Functional involvement of endothelial lipase in hepatitis B virus infection.
Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
Title: Potential role of hepatic lipase in the accretion of docosahexaenoic acid (DHA) by the brain.
FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth.
Title: FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth.
inhibitory activity of AOE on pancreatic lipase enzyme was evaluated at concentrations from 60 to 1000 mug/mL. The AOE inhibited the pancreatic lipase with an IC50 = 588.5 mug/mL
Title: Hypocholesterolemic Effect and In Vitro Pancreatic Lipase Inhibitory Activity of an Opuntia ficus-indica Extract.
Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids.
Title: Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.
Furin has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase in hepatocytes
Title: Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
The role of EL in HDL-associated S1P effects provides new insights into EL action, the responses seen through EL and HDL interaction, and S1P signaling.
Title: Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.
Endothelial lipase may act as an alternative candidate to provide fatty acids to the heart and regulate cardiac function.
Title: Endothelial lipase modulates pressure overload-induced heart failure through alternative pathway for fatty acid uptake.
Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Title: Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Endothelial lipase supplies cells with free fatty acids and HDL-derived lysophosphatidylcholine and lysophosphatidylethanolamine species resulting in increased cellular triglycerides and phosphatidylcholine (PC) content and decreased PC synthesis.
Title: Impact of endothelial lipase on cellular lipid composition.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA963895 (e-PCR)
- UniSTS:248119

Lipg (e-PCR), detects polymorphism
- UniSTS:507029

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelial lipase

Names: EDL; endothelial cell-derived lipase; lipose, endothelial; phospholipase A1

NP_034850.3

EC 3.1.1.3

EC 3.1.1.32

XP_006525755.1

EC 3.1.1.3

EC 3.1.1.32

XP_036016892.1

EC 3.1.1.3

EC 3.1.1.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010720.3 → NP_034850.3 endothelial lipase precursor

See identical proteins and their annotated locations for NP_034850.3

Status: VALIDATED

Source sequence(s)

AK014047, AK150054, AK152161, AK152430, AK152872

Consensus CDS

CCDS29343.1

UniProtKB/Swiss-Prot

Q8VDU2, Q9WVG5

UniProtKB/TrEMBL

C0LQ91, Q3TA44, Q3U807

Related

ENSMUSP00000066536.5, ENSMUST00000066532.5

Conserved Domains (3) summary

TIGR03230
Location:51 → 485

lipo_lipase; lipoprotein lipase

cd00707
Location:49 → 340

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:347 → 483

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

75072393..75095380 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160999.1 → XP_036016892.1 endothelial lipase isoform X2

UniProtKB/TrEMBL

Q3TA44, Q3U807

Conserved Domains (1) summary

TIGR03230
Location:2 → 405

lipo_lipase; lipoprotein lipase
XM_006525692.4 → XP_006525755.1 endothelial lipase isoform X1

UniProtKB/TrEMBL

Q3TA44, Q3U807

Conserved Domains (1) summary

TIGR03230
Location:25 → 416

lipo_lipase; lipoprotein lipase