Vamp1 vesicle-associated membrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vamp1provided by MGI
Official Full Name: vesicle-associated membrane protein 1provided by MGI
Primary source: MGI:MGI:1313276
See related: Ensembl:ENSMUSG00000030337 AllianceGenome:MGI:1313276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lew; Syb1; Syb-1; VAMP-1
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in cell surface. Is active in glutamatergic synapse and neuromuscular junction. Is expressed in brain; cerebellum molecular layer; and ventral tegmental area. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 144.0), thymus adult (RPKM 114.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 59.32 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125192544..125199269)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125215581..125222306)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.
Title: microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.
Vamp1 is strongly down-regulated in Rbfox1 knock-out mice which contributes to regulation of synaptic transmission.
Title: Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.
These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE complex protein VAMP1 (synaptobrevin-1) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens
Title: Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter.
residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates.
Title: Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
Genetically regulated VAMP1 expression in the brain may modify both Alzheimer's disease risk and may contribute to Alzheimer's pathophysiology
Title: Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility.
Vesicle release in syb2 KO cultured neurons was massively reduced by a knockdown of syb1, demonstrating that syb1 is responsible for the remaining release activity.
Title: Synaptobrevin 1 mediates vesicle priming and evoked release in a subpopulation of hippocampal neurons.
A null mutation of Syb1 resulting from a spontaneous, nonsense mutation in mice significantly impairs the function, but not the structure, of the neuromuscular junction.
Title: The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction.
the trigger site in synaptobrevin is crucial for productive SNARE zippering
Title: A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.
VAMP1 is selectively expressed in the retina and in discrete areas of the brain including the zona incerta and rostral periolivary region in murine lethal wasting disease.
Title: A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant.
CGRP was found to occur in the majority of neurons from rat trigeminal ganglia, together with the three exocytotic SNAREs [SNAP25, syntaxin 1 and the synaptobrevin (Sbr, also known as VAMP) isoforms] and synaptotagmin.
Title: Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94634 (e-PCR)
- UniSTS:119881

Vamp1 (e-PCR), detects polymorphism
- UniSTS:144742

BE292615 (e-PCR)
- UniSTS:208035

RH125149 (e-PCR)
- UniSTS:161971

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle priming	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle priming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in specific granule membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in tertiary granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicle-associated membrane protein 1

Names: synaptobrevin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080557.1 → NP_001074026.1 vesicle-associated membrane protein 1 isoform b

See identical proteins and their annotated locations for NP_001074026.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AK018783, BC057587, BU700508, BY640283

Consensus CDS

CCDS39637.1

UniProtKB/TrEMBL

A0A0N4SUV3

Related

ENSMUSP00000098503.3, ENSMUST00000100942.9

Conserved Domains (2) summary

cd15870
Location:32 → 94

R-SNARE_VAMP2; SNARE motif of VAMP2

pfam00957
Location:30 → 102

Synaptobrevin; Synaptobrevin
NM_009496.3 → NP_033522.1 vesicle-associated membrane protein 1 isoform a

See identical proteins and their annotated locations for NP_033522.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a)

Source sequence(s)

AK018783, BU700508, BY640283

Consensus CDS

CCDS20546.1

UniProtKB/Swiss-Prot

Q62442, Q6PFF3, Q810K6

UniProtKB/TrEMBL

A0A0N4SUV3

Related

ENSMUSP00000032487.8, ENSMUST00000032487.14

Conserved Domains (1) summary

cd15870
Location:32 → 94

R-SNARE_VAMP2; SNARE motif of VAMP2