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    Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 19417, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rasgrf1provided by MGI
    Official Full Name
    RAS protein-specific guanine nucleotide-releasing factor 1provided by MGI
    Primary source
    MGI:MGI:99694
    See related
    Ensembl:ENSMUSG00000032356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grf; Gnrp; Grf1; p190; CDC25; Grfbe; P190-A; CDC25Mm; Grfbeta; AI844718; Ras-GRF1; p190RhoGEF
    Expression
    Biased expression in cerebellum adult (RPKM 26.4), frontal lobe adult (RPKM 25.1) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rasgrf1 in Genome Data Viewer
    Location:
    9 E3.1; 9 47.31 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89791565..89909032)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (89909508..90026979)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (89804613..89921817)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930524O08 gene Neighboring gene microRNA 184 Neighboring gene thymidine kinase 1 pseudogene Neighboring gene cathepsin H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of NMDA receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-specific guanine nucleotide-releasing factor 1
    Names
    Ras guanine release factor beta
    ras-specific nucleotide exchange factor CDC25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039655.1NP_001034744.1  ras-specific guanine nucleotide-releasing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001034744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and uses an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 2, also known as GRF beta) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102545, AK140227
      Consensus CDS
      CCDS40723.1
      UniProtKB/TrEMBL
      Q9QZR7
      Related
      ENSMUSP00000034909.5, ENSMUST00000034909.11
      Conserved Domains (2) summary
      pfam00169
      Location:2482
      PH; PH domain
      cl17171
      Location:1992
      PH-like; Pleckstrin homology-like domain
    2. NM_001357743.1NP_001344672.1  ras-specific guanine nucleotide-releasing factor 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
      Source sequence(s)
      AC102545
      Conserved Domains (6) summary
      smart00147
      Location:10211257
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00325
      Location:246427
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam00618
      Location:636685
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:925994
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl17171
      Location:19155
      PH-like; Pleckstrin homology-like domain
      cl25508
      Location:105218
      Spc7; Spc7 kinetochore protein
    3. NM_001357744.1NP_001344673.1  ras-specific guanine nucleotide-releasing factor 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' coding exons and uses an alternate 3' terminal exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102545, DV043084
      Conserved Domains (1) summary
      cl17171
      Location:19108
      PH-like; Pleckstrin homology-like domain
    4. NM_011245.2NP_035375.1  ras-specific guanine nucleotide-releasing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_035375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC102545, AK079638, AK140380, CD775453
      Consensus CDS
      CCDS40722.1
      UniProtKB/Swiss-Prot
      P27671
      UniProtKB/TrEMBL
      B2RS27
      Related
      ENSMUSP00000034912.5, ENSMUST00000034912.6
      Conserved Domains (6) summary
      smart00147
      Location:10231259
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00325
      Location:248429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam00169
      Location:24130
      PH; PH domain
      pfam00618
      Location:638687
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:927996
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl17171
      Location:19155
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      89791565..89909032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154723.1XP_036010616.1  ras-specific guanine nucleotide-releasing factor 1 isoform X1

      Conserved Domains (4) summary
      smart00147
      Location:597833
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      pfam00618
      Location:212261
      RasGEF_N; RasGEF N-terminal motif
      cl02520
      Location:501570
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cl17171
      Location:9160
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_001778822.3 RNA Sequence

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