Mmd monocyte to macrophage differentiation-associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmdprovided by MGI
Official Full Name: monocyte to macrophage differentiation-associatedprovided by MGI
Primary source: MGI:MGI:1914718
See related: Ensembl:ENSMUSG00000003948 AllianceGenome:MGI:1914718
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Paqr11; 1200017E07Rik; 1810073C06Rik
Summary: Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; cranial ganglion; musculoskeletal system; nose; and retina. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 114.9), genital fat pad adult (RPKM 66.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 54.89 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (90078513..90169399)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90249276..90278573)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
Title: Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
Title: PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis.
These results suggested that MMD modulates TNF-alpha and NO production in macrophages, and this process might involves Erk or Akt.
Title: Monocyte to macrophage differentiation-associated (MMD) positively regulates ERK and Akt activation and TNF-α and NO production in macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D11Mit286 (e-PCR), detects polymorphism
- UniSTS:126493

D11Dcr16 (e-PCR), detects polymorphism
- UniSTS:507459

D11Mit357 (e-PCR), detects polymorphism
- UniSTS:126573

AA690185 (e-PCR)
- UniSTS:160142

D10Chm112 (e-PCR)
- UniSTS:518039

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocyte to macrophage differentiation factor

Names: monocyte to macrophage differentiation protein; progestin and adipoQ receptor family member 11; progestin and adipoQ receptor family member XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395423.1 → NP_001382352.1 monocyte to macrophage differentiation factor isoform 2

Status: VALIDATED

Source sequence(s)

AL626785, AL645990

UniProtKB/TrEMBL

Q3UE73

Conserved Domains (1) summary

TIGR01065
Location:28 → 228

hlyIII; channel protein, hemolysin III family
NM_026178.2 → NP_080454.1 monocyte to macrophage differentiation factor isoform 1

See identical proteins and their annotated locations for NP_080454.1

Status: VALIDATED

Source sequence(s)

BC021914

Consensus CDS

CCDS25240.1

UniProtKB/Swiss-Prot

Q3TAU1, Q5SVU7, Q9CQY7

UniProtKB/TrEMBL

Q3UE73

Related

ENSMUSP00000004050.7, ENSMUST00000004050.7

Conserved Domains (1) summary

TIGR01065
Location:27 → 227

hlyIII; channel protein, hemolysin III family