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    Ccnl1 cyclin L1 [ Mus musculus (house mouse) ]

    Gene ID: 56706, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ccnl1provided by MGI
    Official Full Name
    cyclin L1provided by MGI
    Primary source
    MGI:MGI:1922664
    See related
    Ensembl:ENSMUSG00000027829 AllianceGenome:MGI:1922664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccnl; ania-6a; 2610030E23Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in head. Orthologous to human CCNL1 (cyclin L1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 21.2), thymus adult (RPKM 20.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccnl1 in Genome Data Viewer
    Location:
    3 E1; 3 30.25 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65853333..65869451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (65945908..65962029, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54198 Neighboring gene STARR-positive B cell enhancer ABC_E9008 Neighboring gene predicted gene, 35039 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:65761281-65761390 Neighboring gene STARR-seq mESC enhancer starr_07873 Neighboring gene 40S ribosomal protein S27-like pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel cyclin provides a link between dopamine and RNA processing. Nairn AC, et al. Neuron, 2001 Oct 25. PMID 11683987
    2. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. Sgambato V, et al. J Neurochem, 2003 Jul. PMID 12807435
    3. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen HH, et al. Biochem Biophys Res Commun, 2007 Mar 16. PMID 17261272
    4. CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis. Rakkaa T, et al. Chromosome Res, 2014 Sep. PMID 24436071
    5. CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway. Yun X, et al. Mol Cell Biochem, 2007 Oct. PMID 17516030

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of centrosome cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-L1
    Names
    cyclin ania-6a
    cyclin-L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355432.1 → NP_001342361.1  cyclin-L1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165307, BC094383
      Conserved Domains (1) summary
      cl28538
      Location:41 → 139
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    2. NM_001355433.1 → NP_001342362.1  cyclin-L1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165307, BC094383
      Conserved Domains (1) summary
      cl28538
      Location:21 → 119
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    3. NM_019937.4 → NP_064321.2  cyclin-L1 isoform 1

      See identical proteins and their annotated locations for NP_064321.2

      Status: VALIDATED

      Source sequence(s)
      AC165307, BC094383, CJ150556
      Consensus CDS
      CCDS17390.1
      UniProtKB/Swiss-Prot
      Q52KE7, Q8BQ75, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44
      Related
      ENSMUSP00000029416.8, ENSMUST00000029416.14
      Conserved Domains (2) summary
      smart00385
      Location:211 → 280
      CYCLIN; domain present in cyclins, TFIIB and Retinoblastoma
      cd00043
      Location:88 → 160
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      65853333..65869451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252700.2 → XP_030108560.1  cyclin-L1 isoform X1

      Conserved Domains (1) summary
      COG5333
      Location:39 → 137
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    2. XM_036163178.1 → XP_036019071.1  cyclin-L1 isoform X2

      Related
      ENSMUST00000122919.8
      Conserved Domains (1) summary
      cl40454
      Location:5 → 100
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_036163179.1 → XP_036019072.1  cyclin-L1 isoform X2

      Conserved Domains (1) summary
      cl40454
      Location:5 → 100
      CYCLIN_SF; Cyclin box fold superfamily

    4. XM_011240174.4 → XP_011238476.1  cyclin-L1 isoform X3

      Conserved Domains (1) summary
      COG5333
      Location:80 → 233
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

    RNA

    1. XR_867222.4 RNA Sequence

    2. XR_004941367.1 RNA Sequence

    3. XR_004941366.1 RNA Sequence

    4. XR_004941368.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025442.1: Suppressed sequence

      Description
      NM_001025442.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.

    2. NM_001025443.1: Suppressed sequence

      Description
      NM_001025443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KE7.1 GenPept UniProtKB/Swiss-Prot:Q52KE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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