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    Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11931, updated on 20-Jul-2021

    Summary

    Official Symbol
    Atp1b1provided by MGI
    Official Full Name
    ATPase, Na+/K+ transporting, beta 1 polypeptideprovided by MGI
    Primary source
    MGI:MGI:88108
    See related
    Ensembl:ENSMUSG00000026576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    At; Atpb; Atp4b; Atpb-1; NKbeta1
    Summary
    This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in cerebellum adult (RPKM 397.4), kidney adult (RPKM 397.3) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp1b1 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.75 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164264668..164285924, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164437099..164458355, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (166367398..166388486, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene NME/NM23 family member 7 Neighboring gene predicted gene, 39690 Neighboring gene predicted gene, 32391 Neighboring gene predicted gene, 39691

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metal ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in relaxation of cardiac muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of sodium:potassium-exchanging ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of sodium:potassium-exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1
    Names
    sodium/potassium ATPase beta subunit
    sodium/potassium-dependent ATPase subunit beta-1
    NP_033851.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009721.6NP_033851.1  sodium/potassium-transporting ATPase subunit beta-1

      See identical proteins and their annotated locations for NP_033851.1

      Status: REVIEWED

      Source sequence(s)
      AK005071, AK010677, AK160405
      Consensus CDS
      CCDS35755.1
      UniProtKB/Swiss-Prot
      P14094
      UniProtKB/TrEMBL
      Q3TV47, Q545P0
      Related
      ENSMUSP00000027863.8, ENSMUST00000027863.13
      Conserved Domains (1) summary
      TIGR01107
      Location:1304
      Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164264668..164285924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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