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    Napg N-ethylmaleimide sensitive fusion protein attachment protein gamma [ Mus musculus (house mouse) ]

    Gene ID: 108123, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Napgprovided by MGI
    Official Full Name
    N-ethylmaleimide sensitive fusion protein attachment protein gammaprovided by MGI
    Primary source
    MGI:MGI:104561
    See related
    Ensembl:ENSMUSG00000024581 AllianceGenome:MGI:104561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNARE; 2400003O04Rik
    Summary
    Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Located in myelin sheath. Orthologous to human NAPG (NSF attachment protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 25.8), frontal lobe adult (RPKM 24.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E1; 18 35.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63110910..63132521)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62977836..62999450)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41752 Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene piezo-type mechanosensitive ion channel component 2 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The sequence complexity of exons trapped from the mouse genome. Nehls M, et al. Curr Biol, 1994 Nov 1. PMID 7874497
    2. A new beat for the SNARE drum. Götte M, et al. Trends Cell Biol, 1998 Jun. PMID 9695844
    3. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen D, et al. J Biol Chem, 2001 Apr 20. PMID 11278501
    4. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. Advani RJ, et al. J Biol Chem, 1998 Apr 24. PMID 9553086
    5. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. Lin SS, et al. J Biol Chem, 2006 Aug 11. PMID 16717086

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-soluble NSF attachment protein
    Names
    N-ethylmaleimide-sensitive factor attachment protein gamma
    SNAP-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419376.1 → NP_001406305.1  gamma-soluble NSF attachment protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140554
      Related
      ENSMUSP00000122681.2, ENSMUST00000150267.2

    2. NM_001419381.1 → NP_001406310.1  gamma-soluble NSF attachment protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140554
      UniProtKB/TrEMBL
      A0A494BAE3
      Related
      ENSMUSP00000158047.2, ENSMUST00000235372.2

    3. NM_028017.2 → NP_082293.1  gamma-soluble NSF attachment protein isoform 1

      See identical proteins and their annotated locations for NP_082293.1

      Status: VALIDATED

      Source sequence(s)
      AC140554
      Consensus CDS
      CCDS29295.1
      UniProtKB/Swiss-Prot
      Q3TPT4, Q9CWZ7
      UniProtKB/TrEMBL
      Q8C1T5
      Related
      ENSMUSP00000025474.7, ENSMUST00000025474.14
      Conserved Domains (1) summary
      cd15832
      Location:8 → 278
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      63110910..63132521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246809.4 → XP_011245111.1  gamma-soluble NSF attachment protein isoform X3

      See identical proteins and their annotated locations for XP_011245111.1

      UniProtKB/TrEMBL
      A0A494BA20
      Conserved Domains (2) summary
      cd15832
      Location:24 → 59
      SNAP; TPR repeat [structural motif]
      cl24038
      Location:5 → 241
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. XM_011246807.3 → XP_011245109.1  gamma-soluble NSF attachment protein isoform X2

      UniProtKB/TrEMBL
      A0A494BA20
      Conserved Domains (2) summary
      cd15832
      Location:29 → 64
      SNAP; TPR repeat [structural motif]
      cl24038
      Location:1 → 246
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    3. XM_011246808.4 → XP_011245110.1  gamma-soluble NSF attachment protein isoform X3

      See identical proteins and their annotated locations for XP_011245110.1

      UniProtKB/TrEMBL
      A0A494BA20
      Conserved Domains (2) summary
      cd15832
      Location:24 → 59
      SNAP; TPR repeat [structural motif]
      cl24038
      Location:5 → 241
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWZ7.1 GenPept UniProtKB/Swiss-Prot:Q9CWZ7

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