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    Mtss1 MTSS I-BAR domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 211401, updated on 3-Aug-2021

    Summary

    Official Symbol
    Mtss1provided by MGI
    Official Full Name
    MTSS I-BAR domain containing 1provided by MGI
    Primary source
    MGI:MGI:2384818
    See related
    Ensembl:ENSMUSG00000022353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MI; Mim; BC024131; mKIAA0429; 2310003N14Rik; D130001D01Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 26.2), CNS E18 (RPKM 25.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mtss1 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58813083..58955805, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58941234..59083956, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (58772789..58913581, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene RIKEN cDNA 4930544F09 gene Neighboring gene ribosomal protein L7, pseudogene 8 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37896

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to fluid shear stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell proliferation involved in renal tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerulus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metanephric tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle organ development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein MTSS 1
    Names
    actin monomer-binding protein
    metastasis suppressor 1
    metastasis suppressor protein 1
    missing in metastasis protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146180.1NP_001139652.1  protein MTSS 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in 3' coding region, compared to variant 1. These differences result in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK129139, BY451400, CB518394
      UniProtKB/TrEMBL
      Q6ZQB7
      Conserved Domains (1) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    2. NM_144800.2NP_659049.2  protein MTSS 1 isoform 1

      See identical proteins and their annotated locations for NP_659049.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK030533, AK129139, BY451400, CB518394
      Consensus CDS
      CCDS27496.1
      UniProtKB/Swiss-Prot
      Q8R1S4
      UniProtKB/TrEMBL
      G3X9H7, Q6ZQB7
      Related
      ENSMUSP00000079239.7, ENSMUST00000080371.8
      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:729754
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58813083..58955805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248450.1XP_030104310.1  protein MTSS 1 isoform X27

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:528656
      Gag_spuma; Spumavirus gag protein
    2. XM_030248449.1XP_030104309.1  protein MTSS 1 isoform X25

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330680
      PHA03247; large tegument protein UL36; Provisional
    3. XM_011245548.3XP_011243850.1  protein MTSS 1 isoform X23

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330728
      PHA03247; large tegument protein UL36; Provisional
    4. XM_036159298.1XP_036015191.1  protein MTSS 1 isoform X11

      Conserved Domains (3) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330745
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:743773
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
    5. XM_011245543.3XP_011243845.1  protein MTSS 1 isoform X7

      Conserved Domains (3) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:339765
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:628756
      Gag_spuma; Spumavirus gag protein
    6. XM_006520712.4XP_006520775.1  protein MTSS 1 isoform X19

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:583711
      Gag_spuma; Spumavirus gag protein
    7. XM_011245545.3XP_011243847.1  protein MTSS 1 isoform X13

      Conserved Domains (3) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:499768
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:603731
      Gag_spuma; Spumavirus gag protein
    8. XM_006520709.4XP_006520772.1  protein MTSS 1 isoform X5

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:633761
      Gag_spuma; Spumavirus gag protein
    9. XM_011245542.3XP_011243844.1  protein MTSS 1 isoform X3

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:653781
      Gag_spuma; Spumavirus gag protein
    10. XM_006520707.4XP_006520770.1  protein MTSS 1 isoform X4

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:648776
      Gag_spuma; Spumavirus gag protein
    11. XM_011245540.3XP_011243842.1  protein MTSS 1 isoform X1

      Conserved Domains (3) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:564833
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:668796
      Gag_spuma; Spumavirus gag protein
    12. XM_030248443.1XP_030104303.1  protein MTSS 1 isoform X8

      Conserved Domains (3) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:335761
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:624752
      Gag_spuma; Spumavirus gag protein
    13. XM_011245541.3XP_011243843.1  protein MTSS 1 isoform X2

      Conserved Domains (3) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:560829
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:664792
      Gag_spuma; Spumavirus gag protein
    14. XM_036159299.1XP_036015192.1  protein MTSS 1 isoform X26

      Conserved Domains (3) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326676
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:674704
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
    15. XM_030248448.2XP_030104308.1  protein MTSS 1 isoform X24

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326724
      PHA03247; large tegument protein UL36; Provisional
    16. XM_017316531.3XP_017172020.1  protein MTSS 1 isoform X14

      Conserved Domains (3) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:495764
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:599727
      Gag_spuma; Spumavirus gag protein
    17. XM_030248442.2XP_030104302.1  protein MTSS 1 isoform X6

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:629757
      Gag_spuma; Spumavirus gag protein
    18. XM_011245546.2XP_011243848.1  protein MTSS 1 isoform X17

      Conserved Domains (3) summary
      PHA03247
      Location:483752
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:587715
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1160
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    19. XM_011245547.2XP_011243849.1  protein MTSS 1 isoform X20

      Conserved Domains (3) summary
      PHA03247
      Location:479748
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:583711
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1156
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    20. XM_011245544.1XP_011243846.1  protein MTSS 1 isoform X10

      Conserved Domains (3) summary
      PHA03247
      Location:505774
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:609737
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:9182
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    21. XM_017316532.2XP_017172021.1  protein MTSS 1 isoform X21

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:568696
      Gag_spuma; Spumavirus gag protein
    22. XM_030248446.2XP_030104306.1  protein MTSS 1 isoform X16

      Conserved Domains (2) summary
      cd07643
      Location:7241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:588716
      Gag_spuma; Spumavirus gag protein
    23. XM_006520711.5XP_006520774.1  protein MTSS 1 isoform X15

      Conserved Domains (3) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326726
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:589717
      Gag_spuma; Spumavirus gag protein
    24. XM_006520714.5XP_006520777.1  protein MTSS 1 isoform X22

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:564692
      Gag_spuma; Spumavirus gag protein
    25. XM_030248447.2XP_030104307.1  protein MTSS 1 isoform X18

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:584712
      Gag_spuma; Spumavirus gag protein
    26. XM_030248452.2XP_030104312.1  protein MTSS 1 isoform X30

      Conserved Domains (2) summary
      pfam03276
      Location:483611
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1156
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    27. XM_006520717.3XP_006520780.1  protein MTSS 1 isoform X29

      Conserved Domains (3) summary
      PHA03247
      Location:249649
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:512640
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1160
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    28. XM_030248444.1XP_030104304.1  protein MTSS 1 isoform X9

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:609737
      Gag_spuma; Spumavirus gag protein
    29. XM_030248445.2XP_030104305.1  protein MTSS 1 isoform X12

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326741
      PHA03247; large tegument protein UL36; Provisional
    30. XM_030248451.2XP_030104311.1  protein MTSS 1 isoform X28

      Conserved Domains (2) summary
      cd07643
      Location:7237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:524652
      Gag_spuma; Spumavirus gag protein
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