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    Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 [ Mus musculus (house mouse) ]

    Gene ID: 76594, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dnajc18provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C18provided by MGI
    Primary source
    MGI:MGI:1923844
    See related
    Ensembl:ENSMUSG00000024350 AllianceGenome:MGI:1923844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700075B01Rik
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; gut gland; sensory organ; and skeleton. Orthologous to human DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 10.7), frontal lobe adult (RPKM 10.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 B2; 18 19.21 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35804156..35841467, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35671103..35708418, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene proline rich basic protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7578 Neighboring gene spermatogenesis associated 24 Neighboring gene STARR-seq mESC enhancer starr_44246 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene STARR-positive B cell enhancer mm9_chr18:35889997-35890297 Neighboring gene small integral membrane protein 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 18
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029669.4 → NP_083945.1  dnaJ homolog subfamily C member 18

      See identical proteins and their annotated locations for NP_083945.1

      Status: VALIDATED

      Source sequence(s)
      AC121821, AC132837
      Consensus CDS
      CCDS29148.1
      UniProtKB/Swiss-Prot
      Q8R371, Q9CZJ9
      Related
      ENSMUSP00000025208.6, ENSMUST00000025208.7
      Conserved Domains (2) summary
      PRK14298
      Location:81 → 182
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:250 → 349
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35804156..35841467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161306.1 → XP_036017199.1  dnaJ homolog subfamily C member 18 isoform X2

      Conserved Domains (2) summary
      PRK14298
      Location:40 → 141
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:208 → 308
      DUF1977; Domain of unknown function (DUF1977)

    2. XM_006526345.4 → XP_006526408.1  dnaJ homolog subfamily C member 18 isoform X1

      See identical proteins and their annotated locations for XP_006526408.1

      UniProtKB/Swiss-Prot
      Q8R371, Q9CZJ9
      Conserved Domains (2) summary
      PRK14298
      Location:81 → 182
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:250 → 349
      DUF1977; Domain of unknown function (DUF1977)

    3. XM_006526343.4 → XP_006526406.1  dnaJ homolog subfamily C member 18 isoform X1

      See identical proteins and their annotated locations for XP_006526406.1

      UniProtKB/Swiss-Prot
      Q8R371, Q9CZJ9
      Conserved Domains (2) summary
      PRK14298
      Location:81 → 182
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:250 → 349
      DUF1977; Domain of unknown function (DUF1977)

    4. XM_006526344.4 → XP_006526407.1  dnaJ homolog subfamily C member 18 isoform X1

      See identical proteins and their annotated locations for XP_006526407.1

      UniProtKB/Swiss-Prot
      Q8R371, Q9CZJ9
      Conserved Domains (2) summary
      PRK14298
      Location:81 → 182
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:250 → 349
      DUF1977; Domain of unknown function (DUF1977)

    5. XM_006526346.4 → XP_006526409.1  dnaJ homolog subfamily C member 18 isoform X2

      Conserved Domains (2) summary
      PRK14298
      Location:40 → 141
      PRK14298; chaperone protein DnaJ; Provisional
      pfam09320
      Location:208 → 308
      DUF1977; Domain of unknown function (DUF1977)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZJ9.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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