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    Scnn1a sodium channel, nonvoltage-gated 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 20276, updated on 23-Jun-2021

    Summary

    Official Symbol
    Scnn1aprovided by MGI
    Official Full Name
    sodium channel, nonvoltage-gated 1 alphaprovided by MGI
    Primary source
    MGI:MGI:101782
    See related
    Ensembl:ENSMUSG00000030340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sc; mEN; ENaC; SCNEA; Scnn1; mENaC
    Expression
    Biased expression in lung adult (RPKM 90.9), colon adult (RPKM 43.3) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Scnn1a in Genome Data Viewer
    Location:
    6 F3; 6 59.32 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125290978..125321906)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125314271..125344943)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (125271358..125294961)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930417O13 gene Neighboring gene tubulin, alpha 3A Neighboring gene lymphotoxin B receptor Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6 Neighboring gene predicted gene, 52918

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ligand-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ligand-gated sodium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to ligand-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of sodium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amiloride-sensitive sodium channel subunit alpha
    Names
    ENaC alpha
    alpha-ENaC
    alpha-NaCH
    amiloride-sensitive epithelial sodium channel
    epithelial Na(+) channel subunit alpha
    epithelial sodium channel alpha subunit
    nonvoltage-gated sodium channel 1 subunit alpha
    sodium channel, nonvoltage-gated, type I, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011324.2NP_035454.2  amiloride-sensitive sodium channel subunit alpha

      See identical proteins and their annotated locations for NP_035454.2

      Status: VALIDATED

      Source sequence(s)
      AC140324, AF112185, AK140389
      Consensus CDS
      CCDS39641.2
      UniProtKB/Swiss-Prot
      Q61180
      UniProtKB/TrEMBL
      Q3USG4
      Related
      ENSMUSP00000080164.8, ENSMUST00000081440.14
      Conserved Domains (2) summary
      TIGR00859
      Location:80677
      ENaC; sodium channel transporter
      TIGR00867
      Location:88600
      deg-1; degenerin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125290978..125321906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255276.2XP_030111136.1  amiloride-sensitive sodium channel subunit alpha isoform X2

      Conserved Domains (1) summary
      cl02990
      Location:1349
      ASC; Amiloride-sensitive sodium channel
    2. XM_017321471.3XP_017176960.1  amiloride-sensitive sodium channel subunit alpha isoform X1

      Conserved Domains (1) summary
      TIGR00859
      Location:25539
      ENaC; sodium channel transporter
    3. XM_036165971.1XP_036021864.1  amiloride-sensitive sodium channel subunit alpha isoform X2

      Conserved Domains (1) summary
      cl02990
      Location:1349
      ASC; Amiloride-sensitive sodium channel
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