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    Oscar osteoclast associated receptor [ Mus musculus (house mouse) ]

    Gene ID: 232790, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Oscarprovided by MGI
    Official Full Name
    osteoclast associated receptorprovided by MGI
    Primary source
    MGI:MGI:2179720
    See related
    Ensembl:ENSMUSG00000054594 AllianceGenome:MGI:2179720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3
    Summary
    Enables collagen receptor activity. Acts upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface. Is expressed in testis. Orthologous to human OSCAR (osteoclast associated Ig-like receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 1.4), testis adult (RPKM 1.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 2.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3612812..3619156, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3609813..3616157, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35037 Neighboring gene predicted gene, 45920 Neighboring gene STARR-seq mESC enhancer starr_17907 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene STARR-seq mESC enhancer starr_17908 Neighboring gene STARR-seq mESC enhancer starr_17909 Neighboring gene STARR-seq mESC enhancer starr_17910 Neighboring gene STARR-seq mESC enhancer starr_17911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:3581200-3581309 Neighboring gene STARR-positive B cell enhancer ABC_E2811 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene TCF3 (E2A) fusion partner

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Park DR, et al. Nat Commun, 2020 Aug 28. PMID 32859940, Free PMC Article
    2. Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro. Sinningen K, et al. Biochem Biophys Res Commun, 2013 Jul 26. PMID 23817038
    3. Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. Kim Y, et al. J Biol Chem, 2005 Sep 23. PMID 16046394
    4. Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression. So H, et al. J Biol Chem, 2003 Jun 27. PMID 12695521
    5. Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation. Kim JH, et al. J Mol Biol, 2008 Nov 14. PMID 18762192

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
      Title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
    2. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis
      Title: Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.
    3. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
      Title: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
    4. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
      Title: Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
    5. OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis
      Title: Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
    6. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts
      Title: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
    7. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation
      Title: Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).
    8. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade.
      Title: Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.
    9. The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
      Title: Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables collagen receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Fc-gamma receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within interleukin-2 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-2 production IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within multinuclear osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    osteoclast-associated immunoglobulin-like receptor
    Names
    ocl178
    osteoclast-associated receptor OSCAR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290377.1 → NP_001277306.1  osteoclast-associated immunoglobulin-like receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001277306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF391159, AF391160
      Consensus CDS
      CCDS71872.1
      UniProtKB/Swiss-Prot
      Q8VBT3, Q8VHT9
      UniProtKB/TrEMBL
      B2RQ61
      Related
      ENSMUSP00000104285.2, ENSMUST00000108645.8
      Conserved Domains (1) summary
      cl11960
      Location:30 → 123
      Ig; Immunoglobulin domain

    2. NM_175632.3 → NP_783440.1  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_783440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF391160, AF391161
      Consensus CDS
      CCDS20718.1
      UniProtKB/TrEMBL
      B2RQ61
      Related
      ENSMUSP00000041306.8, ENSMUST00000039507.15
      Conserved Domains (1) summary
      cl11960
      Location:36 → 129
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3612812..3619156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBT3.1 GenPept UniProtKB/Swiss-Prot:Q8VBT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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