Hrh4 histamine receptor H4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hrh4provided by MGI
Official Full Name: histamine receptor H4provided by MGI
Primary source: MGI:MGI:2429635
See related: Ensembl:ENSMUSG00000037346 AllianceGenome:MGI:2429635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
Summary: Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and inflammatory response. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Orthologous to human HRH4 (histamine receptor H4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.0) and spleen adult (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 6.88 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (13140039..13156758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (13006982..13023701)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice.
Title: The Interplay between Histamine H(4) Receptor and the Kidney Function: The Lesson from H(4) Receptor Knockout Mice.
The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
Title: The Histamine H(4) Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A(3) Receptor Agonist IB-MECA: Role of CD4(+) T Cells.
The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
Title: The Novel H(4)R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma.
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Title: Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Findings show an effective role of HrH4 in adipose tissue browning.
Title: Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue.
Study using adoptive transfer of eosinophils from H4R-deficient and H4R-competentmice to dextran sodium sulfate-induced colitis in IL-5-deficient mice demonstrate that as well as in vitro, also in vivo histamine via the H4R only partially activates eosinophils.
Title: In vivo Evidence for Partial Activation of Eosinophils via the Histamine H(4)-Receptor: Adoptive Transfer Experiments Using Eosinophils From H(4)R(-/-) and H(4)R(+/+) Mice.
Rac1 and Rac2 have distinct and essential roles in intracellular signaling downstream of H4 receptor-PI3K in histamine-induced chemotaxis of mast cells
Title: Distinct Roles of Small GTPases Rac1 and Rac2 in Histamine H(4) Receptor-Mediated Chemotaxis of Mast Cells.
Study results indicate that persistent ERK activation via the histamine H4 receptor in spinal neurons underlies dinitrofluorobenzene-induced chronic itch.
Title: Persistent Extracellular Signal-Regulated Kinase Activation by the Histamine H4 Receptor in Spinal Neurons Underlies Chronic Itch.
Results suggest that TNF-alpha mRNA expression via histamine H4 receptors may contribute to the development of cisplatin-induced anorexia, and that histamine H4 receptor antagonists are potentially useful treatments.
Title: Effects of a histamine H(4) receptor antagonist on cisplatin-induced anorexia in mice.
colonic mast cells-derived histamine initiates granulocyte infiltration into the colonic mucosa through H4R
Title: Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables histamine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables histamine receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histamine H4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153087.2 → NP_694727.1 histamine H4 receptor

See identical proteins and their annotated locations for NP_694727.1

Status: VALIDATED

Source sequence(s)

AC131672

Consensus CDS

CCDS29069.1

UniProtKB/Swiss-Prot

Q91ZY2

Related

ENSMUSP00000041061.3, ENSMUST00000041676.3

Conserved Domains (1) summary

pfam00001
Location:32 → 360

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

13140039..13156758

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317874.1 → XP_017173363.1 histamine H4 receptor isoform X2

UniProtKB/TrEMBL

B2ZGH2

Related

ENSMUSP00000157130.2, ENSMUST00000234565.2

Conserved Domains (2) summary

cd14964
Location:18 → 42

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:16 → 129

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006525817.2 → XP_006525880.1 histamine H4 receptor isoform X1

See identical proteins and their annotated locations for XP_006525880.1

UniProtKB/TrEMBL

Q2M2N7

Conserved Domains (2) summary

cd14964
Location:5 → 21

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 247

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily