Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmeff1provided by MGI
Official Full Name: transmembrane protein with EGF-like and two follistatin-like domains 1provided by MGI
Primary source: MGI:MGI:1926810
See related: Ensembl:ENSMUSG00000028347 AllianceGenome:MGI:1926810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tr1; TR-1; M7365; A830033E11
Summary: Predicted to be involved in several processes, including animal organ morphogenesis; neuromuscular junction development; and receptor clustering. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Orthologous to several human genes including MSANTD3-TMEFF1 (MSANTD3-TMEFF1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 70.4), CNS E14 (RPKM 69.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.15 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (48585064..48663136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (48585071..48663132)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving.
Title: Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving.
A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC-induced cardiac hypertrophy is through inhibiting TGFbeta non-canonical (TAK1-JNK) pathways in the myocardium.
Title: Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways.
The double-fluorescent immunohistochemical analysis revealed that addicsin and tomoregulin-1 were coexpressed in neurons
Title: Identification of tomoregulin-1 as a novel addicsin-associated factor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AW457727 (e-PCR)
- UniSTS:207616

Tmeff1 (e-PCR), detects polymorphism
- UniSTS:547160

NoName (e-PCR)
- UniSTS:234919

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tomoregulin-1

Names: transmembrane protein with EGF-like and one follistatin-like domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356272.2 → NP_001343201.1 tomoregulin-1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL772151, AL807771

UniProtKB/TrEMBL

A0A0A0MQL0

Related

ENSMUSP00000121740.2, ENSMUST00000130834.8

Conserved Domains (2) summary

smart00280
Location:91 → 135

KAZAL; Kazal type serine protease inhibitors

cl28647
Location:268 → 304

PHA02887; EGF-like protein; Provisional
NM_001426181.1 → NP_001413110.1 tomoregulin-1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL772151, AL807771
NM_021436.4 → NP_067411.1 tomoregulin-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_067411.1

Status: VALIDATED

Source sequence(s)

AL772151, AL807771

Consensus CDS

CCDS18168.1

UniProtKB/Swiss-Prot

A2AJN3, Q6PFE7, Q8BRP7, Q8C536, Q9JJS1

UniProtKB/TrEMBL

A0A0A0MQL0

Related

ENSMUSP00000030032.7, ENSMUST00000030032.13

Conserved Domains (2) summary

PHA02887
Location:267 → 303

PHA02887; EGF-like protein; Provisional

smart00280
Location:91 → 135

KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

48585064..48663136

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537838.2 → XP_006537901.1 tomoregulin-1 isoform X2

UniProtKB/TrEMBL

A0A0A0MQL0

Conserved Domains (2) summary

PHA02887
Location:265 → 301

PHA02887; EGF-like protein; Provisional

smart00280
Location:91 → 135

KAZAL; Kazal type serine protease inhibitors