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    Scrn3 secernin 3 [ Mus musculus (house mouse) ]

    Gene ID: 74616, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Scrn3provided by MGI
    Official Full Name
    secernin 3provided by MGI
    Primary source
    MGI:MGI:1921866
    See related
    Ensembl:ENSMUSG00000008226 AllianceGenome:MGI:1921866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ses3; 4833415E20Rik
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Orthologous to human SCRN3 (secernin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 6.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 43.57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73142980..73168158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73312650..73337818)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene trans-acting transcription factor 9 Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene G protein-coupled receptor 155 Neighboring gene predicted gene 13709 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73224453-73224754 Neighboring gene predicted gene 13707 Neighboring gene WAS/WASL interacting protein family, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception. Bustin KA, et al. Mol Cell Neurosci, 2023 Jun. PMID 36924917,
    2. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Houston BJ, et al. Dev Dyn, 2021 Jul. PMID 33442887, Free PMC Article
    3. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Way G, et al. Mol Biol Cell, 2002 Sep. PMID 12221138, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    secernin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355711.1 → NP_001342640.1  secernin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK050521, BY203757, BY695942
      Consensus CDS
      CCDS89499.1
      UniProtKB/TrEMBL
      A2AWQ9, Q6P6J8
      Related
      ENSMUSP00000107681.2, ENSMUST00000112050.2
      Conserved Domains (1) summary
      cl00467
      Location:5 → 178
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. NM_029022.1 → NP_083298.1  secernin-3 isoform 1

      See identical proteins and their annotated locations for NP_083298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014701, AK028703, AV002033, BE945683, BY203757
      Consensus CDS
      CCDS16128.1
      UniProtKB/Swiss-Prot
      A2AWR0, Q3TMH2, Q91WF6, Q9CUT0
      Related
      ENSMUSP00000088320.5, ENSMUST00000090811.11
      Conserved Domains (1) summary
      cl00467
      Location:5 → 224
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73142980..73168158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162646.1 → XP_036018539.1  secernin-3 isoform X2

      UniProtKB/Swiss-Prot
      A2AWR0, Q3TMH2, Q91WF6, Q9CUT0
      Conserved Domains (1) summary
      cl00467
      Location:5 → 224
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    2. XM_011239820.4 → XP_011238122.1  secernin-3 isoform X3

    3. XM_006500313.5 → XP_006500376.1  secernin-3 isoform X1

      Conserved Domains (1) summary
      cl00467
      Location:28 → 247
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RNA

    1. XR_866344.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TMH2.1 GenPept UniProtKB/Swiss-Prot:Q3TMH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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