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    Xpr1 xenotropic and polytropic retrovirus receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 19775, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Xpr1provided by MGI
    Official Full Name
    xenotropic and polytropic retrovirus receptor 1provided by MGI
    Primary source
    MGI:MGI:97932
    See related
    Ensembl:ENSMUSG00000026469 AllianceGenome:MGI:97932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XR; Sxv; Rmc1; Syg1; Rmc-1
    Summary
    Enables virus receptor activity. Acts upstream of or within response to virus. Predicted to be intrinsic component of plasma membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; lower jaw molar; and neural retina. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 29.3), CNS E18 (RPKM 27.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 G3; 1 66.49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155151403..155293190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155275657..155417444, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene syntaxin 6 Neighboring gene high mobility group protein B3 pseudogene Neighboring gene cDNA sequence BC034090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157081058-157081259 Neighboring gene predicted gene, 31102 Neighboring gene STARR-positive B cell enhancer ABC_E7760 Neighboring gene predicted gene, 17974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157242079-157242280 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157264431-157264732 Neighboring gene STARR-seq mESC enhancer starr_02724 Neighboring gene predicted gene, 31713 Neighboring gene predicted gene, 31772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification. Arase H, et al. Calcif Tissue Int, 2022 Jun. PMID 35112184
    2. Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. Mailer RK, et al. Blood, 2021 Mar 11. PMID 32932519, Free PMC Article
    3. XPR1 Mediates the Pancreatic β-Cell Phosphate Flush. Barker CJ, et al. Diabetes, 2021 Jan. PMID 32826297, Free PMC Article
    4. Analysis of gene expression and functional characterization of XPR1: a pathogenic gene for primary familial brain calcification. Yao XP, et al. Cell Tissue Res, 2017 Nov. PMID 28766044
    5. Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron. Ansermet C, et al. J Am Soc Nephrol, 2017 Apr. PMID 27799484, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification.
      Title: Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification.
    2. Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
      Title: Patterns of Coevolutionary Adaptations across Time and Space in Mouse Gammaretroviruses and Three Restrictive Host Factors.
    3. Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
      Title: Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
    4. XPR1 Mediates the Pancreatic beta-Cell Phosphate Flush.
      Title: XPR1 Mediates the Pancreatic β-Cell Phosphate Flush.
    5. Gene expression profiles showed that XPR1 mRNA was widely expressed throughout the mouse brain.
      Title: Analysis of gene expression and functional characterization of XPR1: a pathogenic gene for primary familial brain calcification.
    6. This study evaluated the effects of XPR1 variants on XPR1 gammaretrovirus entry.
      Title: Escape variants of the XPR1 gammaretrovirus receptor are rare due to reliance on a splice donor site and a short hypervariable loop.
    7. These results show that tobacco leaves are a good heterologous system to study the transport activity of members of the PHO1/XPR1 family.
      Title: Expression of the mammalian Xenotropic Polytropic Virus Receptor 1 (XPR1) in tobacco leaves leads to phosphate export.
    8. subspecies origins of xenotropic and polytropic mouse leukemia virus endogenous retroviruses and their coevolutionary trajectory with their XPR1 receptor
      Title: Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor.
    9. results indicate that Xpr1 is a novel, atypical G-protein-coupled receptor (GPCR) and that xenotropic or polytropic retrovirus binding can disrupt the cAMP-mediated signaling function of Xpr1, leading to the apoptosis of infected cells
      Title: Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.
    10. This study is the first to demonstrate that the expression of retro-viral receptor, XPR1, is regulated by RANKL-RANK signaling.
      Title: RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to virus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 53 member 1
    Names
    phosphate exporter SLC53A1
    receptor for MCF virus 1
    suppressor of yeast G<a> deletion
    susceptibility to xenotropic virus
    xenotropic and polytropic murine leukemia virus receptor
    xenotropic and polytropic retrovirus receptor 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011273.2 → NP_035403.1  solute carrier family 53 member 1

      See identical proteins and their annotated locations for NP_035403.1

      Status: VALIDATED

      Source sequence(s)
      AC110268, AF114753, AF198104, BY122762
      Consensus CDS
      CCDS15384.1
      UniProtKB/Swiss-Prot
      Q3UHG6, Q3UR99, Q8CCC8, Q8CCT2, Q9QZ72, Q9R034, Q9R036, Q9Z0U0
      UniProtKB/TrEMBL
      E3VX20
      Related
      ENSMUSP00000027741.6, ENSMUST00000027741.12
      Conserved Domains (3) summary
      cd14477
      Location:2 → 165
      SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins
      pfam03105
      Location:3 → 169
      SPX; SPX domain
      pfam03124
      Location:286 → 616
      EXS; EXS family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155151403..155293190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R031.1 GenPept UniProtKB/Swiss-Prot:Q9R031
    Q9Z0U0.1 GenPept UniProtKB/Swiss-Prot:Q9Z0U0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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