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    Plekha6 pleckstrin homology domain containing, family A member 6 [ Mus musculus (house mouse) ]

    Gene ID: 240753, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekha6provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family A member 6provided by MGI
    Primary source
    MGI:MGI:2388662
    See related
    Ensembl:ENSMUSG00000041757 AllianceGenome:MGI:2388662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pepp3; 9530028L01Rik
    Summary
    Orthologous to human PLEKHA6 (pleckstrin homology domain containing A6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 32.2), kidney adult (RPKM 14.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E4; 1 57.91 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133089770..133231173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133162032..133303435)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Neighboring gene predicted gene, 51647 Neighboring gene STARR-seq mESC enhancer starr_02276 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135055920-135056124 Neighboring gene VISTA enhancer mm971 Neighboring gene VISTA enhancer mm1460 Neighboring gene STARR-seq mESC enhancer starr_02278 Neighboring gene STARR-seq mESC enhancer starr_02279 Neighboring gene predicted gene, 51648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135134303-135134461 Neighboring gene predicted gene, 19461 Neighboring gene STARR-seq mESC enhancer starr_02280 Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene KiSS-1 metastasis-suppressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maternal DNA Methylation Regulates Early Trophoblast Development. Branco MR, et al. Dev Cell, 2016 Jan 25. PMID 26812015, Free PMC Article
    2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
    3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 6
    Names
    PEPP-3
    PH domain-containing family A member 6
    phosphoinositol 3-phosphate-binding protein-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160268.1 → NP_001153740.1  pleckstrin homology domain-containing family A member 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has several internal in-frame differences compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC158577, AK173074, BB845730
      Consensus CDS
      CCDS48361.1
      UniProtKB/TrEMBL
      A0A087WRB7, E9PX43
      Related
      ENSMUSP00000100703.3, ENSMUST00000105082.9
      Conserved Domains (2) summary
      cd13248
      Location:54 → 177
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:60 → 178
      PH; PH domain

    2. NM_182930.2 → NP_891846.1  pleckstrin homology domain-containing family A member 6 isoform 1

      See identical proteins and their annotated locations for NP_891846.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158577, BB845730, BC054547
      Consensus CDS
      CCDS15292.1
      UniProtKB/Swiss-Prot
      Q7TQG1, Q8K0J5
      UniProtKB/TrEMBL
      A0A087WRB7
      Related
      ENSMUSP00000048214.9, ENSMUST00000038295.15
      Conserved Domains (3) summary
      PRK14086
      Location:232 → 402
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:54 → 157
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:594 → 740
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133089770..133231173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529534.4 → XP_006529597.1  pleckstrin homology domain-containing family A member 6 isoform X1

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:364 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:718 → 864
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    2. XM_017320501.2 → XP_017175990.1  pleckstrin homology domain-containing family A member 6 isoform X3

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:718 → 864
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    3. XM_036164711.1 → XP_036020604.1  pleckstrin homology domain-containing family A member 6 isoform X4

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:658 → 837
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    4. XM_036164712.1 → XP_036020605.1  pleckstrin homology domain-containing family A member 6 isoform X5

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:700 → 846
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    5. XM_006529547.4 → XP_006529610.1  pleckstrin homology domain-containing family A member 6 isoform X7

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (5) summary
      PHA03247
      Location:286 → 664
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:673 → 819
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    6. XM_036164721.1 → XP_036020614.1  pleckstrin homology domain-containing family A member 6 isoform X6

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:671 → 817
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    7. XM_006529553.4 → XP_006529616.1  pleckstrin homology domain-containing family A member 6 isoform X9

      UniProtKB/TrEMBL
      Q69ZU4
      Conserved Domains (4) summary
      PRK14086
      Location:356 → 526
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 281
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:644 → 790
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    8. XM_006529536.4 → XP_006529599.1  pleckstrin homology domain-containing family A member 6 isoform X2

      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (4) summary
      PRK14086
      Location:336 → 506
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 261
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:698 → 844
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    9. XM_006529554.4 → XP_006529617.1  pleckstrin homology domain-containing family A member 6 isoform X10

      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (4) summary
      PRK14086
      Location:336 → 506
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:158 → 261
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:624 → 770
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam00397
      Location:10 → 39
      WW; WW domain

    10. XM_036164730.1 → XP_036020623.1  pleckstrin homology domain-containing family A member 6 isoform X8

      UniProtKB/Swiss-Prot
      Q7TQG1, Q8K0J5
      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (3) summary
      PRK14086
      Location:232 → 402
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:54 → 157
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:594 → 740
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    11. XM_036164736.1 → XP_036020629.1  pleckstrin homology domain-containing family A member 6 isoform X12

      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (3) summary
      PRK14086
      Location:232 → 402
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:54 → 157
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:549 → 695
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    12. XM_030253991.1 → XP_030109851.1  pleckstrin homology domain-containing family A member 6 isoform X11

      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (3) summary
      PRK14086
      Location:232 → 402
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:54 → 157
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:547 → 693
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    13. XM_036164737.1 → XP_036020630.1  pleckstrin homology domain-containing family A member 6 isoform X13

      UniProtKB/TrEMBL
      A0A087WRB7
      Conserved Domains (3) summary
      PRK14086
      Location:232 → 402
      dnaA; chromosomal replication initiator protein DnaA
      cd13248
      Location:54 → 157
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      TIGR04523
      Location:508 → 643
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    RNA

    1. XR_003955328.1 RNA Sequence

    2. XR_387170.4 RNA Sequence

    3. XR_003955340.1 RNA Sequence

    4. XR_003955331.1 RNA Sequence

    5. XR_003955329.1 RNA Sequence

    6. XR_003955337.1 RNA Sequence

    7. XR_003955343.1 RNA Sequence

    8. XR_003955339.1 RNA Sequence

    9. XR_003955344.1 RNA Sequence

    10. XR_003955346.1 RNA Sequence

    11. XR_003955330.1 RNA Sequence

    12. XR_003955348.1 RNA Sequence

    13. XR_003955354.1 RNA Sequence

    14. XR_004942426.1 RNA Sequence

    15. XR_004942424.1 RNA Sequence

    16. XR_004942427.1 RNA Sequence

    17. XR_003955359.1 RNA Sequence

    18. XR_004942428.1 RNA Sequence

    19. XR_003955356.2 RNA Sequence

    20. XR_004942421.1 RNA Sequence

    21. XR_004942420.1 RNA Sequence

    22. XR_003955349.2 RNA Sequence

    23. XR_003955362.2 RNA Sequence

    24. XR_003955353.2 RNA Sequence

    25. XR_003955352.2 RNA Sequence

    26. XR_003955355.2 RNA Sequence

    27. XR_003955345.2 RNA Sequence

    28. XR_003955342.2 RNA Sequence

    29. XR_003955357.1 RNA Sequence

    30. XR_003955341.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQG1.1 GenPept UniProtKB/Swiss-Prot:Q7TQG1

    Gene LinkOut

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