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    Acsl5 acyl-CoA synthetase long-chain family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 433256, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Acsl5provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 5provided by MGI
    Primary source
    MGI:MGI:1919129
    See related
    Ensembl:ENSMUSG00000024981 AllianceGenome:MGI:1919129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACS2; ACS5; Facl5; 1700030F05Rik
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E18 (RPKM 62.0), large intestine adult (RPKM 51.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D2; 19 51.3 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55240298..55285060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55251861..55296628)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46491 Neighboring gene microRNA 6715 Neighboring gene tectorin beta Neighboring gene STARR-seq mESC enhancer starr_46492 Neighboring gene guanylate cyclase 2g Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:55328374-55328561 Neighboring gene STARR-positive B cell enhancer ABC_E8758 Neighboring gene predicted gene, 31595 Neighboring gene STARR-positive B cell enhancer ABC_E7673 Neighboring gene zinc finger, DHHC domain containing 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene STARR-seq mESC enhancer starr_46494 Neighboring gene STARR-seq mESC enhancer starr_46495 Neighboring gene STARR-seq mESC enhancer starr_46496 Neighboring gene STARR-seq mESC enhancer starr_46497 Neighboring gene STARR-seq mESC enhancer starr_46499 Neighboring gene STARR-positive B cell enhancer ABC_E2531 Neighboring gene STARR-positive B cell enhancer ABC_E2532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats. Luo F, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 34923175, Free PMC Article
    2. Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. Bowman TA, et al. Mol Metab, 2016 Mar. PMID 26977393, Free PMC Article
    3. Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption. Meller N, et al. Lipids Health Dis, 2013 Jun 14. PMID 23767941, Free PMC Article
    4. Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation. Hou T, et al. Mol Cell, 2022 Nov 3. PMID 36208627
    5. Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. Marszalek JR, et al. J Biol Chem, 2004 Jun 4. PMID 15051725

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
      Title: Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
    2. Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.
      Title: Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption.
    3. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
      Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oleoyl-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 5
    Names
    LACS 5
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 5
    long-chain acyl-CoA synthetase 5
    NP_082252.1
    XP_006527241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027976.2 → NP_082252.1  long-chain-fatty-acid--CoA ligase 5

      See identical proteins and their annotated locations for NP_082252.1

      Status: VALIDATED

      Source sequence(s)
      AC133100, AI838021, BC031544
      Consensus CDS
      CCDS29908.1
      UniProtKB/Swiss-Prot
      Q8JZR0
      UniProtKB/TrEMBL
      Q3UC67, Q3UKS0
      Related
      ENSMUSP00000046585.5, ENSMUST00000043150.6
      Conserved Domains (1) summary
      cd05927
      Location:101 → 678
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      55240298..55285060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527178.4 → XP_006527241.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

      See identical proteins and their annotated locations for XP_006527241.1

      UniProtKB/Swiss-Prot
      Q8JZR0
      UniProtKB/TrEMBL
      Q3UC67, Q3UKS0
      Conserved Domains (1) summary
      cd05927
      Location:101 → 678
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZR0.1 GenPept UniProtKB/Swiss-Prot:Q8JZR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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