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    Pcgf3 polycomb group ring finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 69587, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pcgf3provided by MGI
    Official Full Name
    polycomb group ring finger 3provided by MGI
    Primary source
    MGI:MGI:1916837
    See related
    Ensembl:ENSMUSG00000033623 AllianceGenome:MGI:1916837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf3; DONG1; RNF3A; E430039C14; 2310035N15Rik; D630042K08Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in histone H2A-K119 monoubiquitination and inactivation of X chromosome by genetic imprinting. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in several structures, including branchial arch; central nervous system; limb; otocyst; and urinary system. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 11.1), CNS E14 (RPKM 9.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcgf3 in Genome Data Viewer
    Location:
    5 F; 5 53.13 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108609082..108654842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108461259..108506976)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene predicted gene, 34319 Neighboring gene ATP synthase membrane subunit e Neighboring gene solute carrier family 49 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6360 Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene complexin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis. Kanki Y, et al. Cell Rep, 2022 Feb 8. PMID 35139389
    2. Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells. Zhao W, et al. J Biol Chem, 2017 Dec 29. PMID 29054931, Free PMC Article
    3. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Fursova NA, et al. Mol Cell, 2019 Jun 6. PMID 31029541, Free PMC Article
    4. Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity. Zhao W, et al. J Biol Chem, 2017 Feb 17. PMID 28049731, Free PMC Article
    5. hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing. Pintacuda G, et al. Mol Cell, 2017 Dec 7. PMID 29220657, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the knockout of Pcgf3, Pcgf5, or both resulted in a 39, 29, and 52% decrease, respectively, in global levels of H2AK119ub1 as compared with wild-type cells, as evidenced by Western blotting. In contrast, no similar change was observed for H3K27me3.
      Title: Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.
    2. Authors conclude that RYBP/YAF2 binding to H2AK119u1 likely underpins the transient interaction of noncanonical PRC1 complexes with Xist RNA domains but does not account for stable interaction of PCGF3/5-PRC1 complexes.
      Title: PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
    3. hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing.
      Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AK119 ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in random inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 3
    Names
    RING finger protein 3A
    ring finger protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377000.1 → NP_001363929.1  polycomb group RING finger protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC158912
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 226
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    2. NM_001377001.1 → NP_001363930.1  polycomb group RING finger protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC158912
      UniProtKB/Swiss-Prot
      Q8BTQ0, Q8BZT0
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 235
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    3. NM_172716.5 → NP_766304.2  polycomb group RING finger protein 3 isoform 1

      See identical proteins and their annotated locations for NP_766304.2

      Status: VALIDATED

      Source sequence(s)
      AC133896, AC158912
      Consensus CDS
      CCDS19512.1
      UniProtKB/Swiss-Prot
      Q8BTQ0, Q8BZT0
      Related
      ENSMUSP00000041790.6, ENSMUST00000046975.12
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 235
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108609082..108654842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165475.1 → XP_036021368.1  polycomb group RING finger protein 3 isoform X1

      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 226
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    2. XM_036165477.1 → XP_036021370.1  polycomb group RING finger protein 3 isoform X3

      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cl28922
      Location:153 → 203
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_030254794.2 → XP_030110654.1  polycomb group RING finger protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q8BTQ0, Q8BZT0
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 235
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    4. XM_036165476.1 → XP_036021369.1  polycomb group RING finger protein 3 isoform X1

      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 226
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTQ0.1 GenPept UniProtKB/Swiss-Prot:Q8BTQ0

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